A study of response to Burkholdaria cepacia
Joint Authors
Abbas, Ala Fahim
Kadum, Samah Ahmad
Source
al-Kufa University Journal for Biology
Issue
Vol. 9, Issue 2 (31 Aug. 2017), pp.55-64, 10 p.
Publisher
University of Kufa Faculty of Science Department of live Sciences
Publication Date
2017-08-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
The current study was aimed to evaluate immune response induced by Burkholdaria cepacia antigens to determine whether these antigens could be a useful immunogen for vaccine development against this bacteria.
Four successive doses of OMP and killed antigen extracted from B.
cepacia isolated from sputum of patients with lower respiratory tract infections were injected into rabbits using multisite injection protocol.
We found that these antigens stimulate specific mucosal and systemic humoral immunoglobulin titers as well as to the significant increased (p ≤ 0.05) in the total protein concentrations at serum and mucosal respiratory secretions in addition to the significant increase in the concentrations of IgG, IgA, IgM at rabbits sera.
INF-γ concentrations were significant increased at serum and mucosal levels with stimulation of migration inhibition index of leukocytes.
These immunogen induced positive skin test tuberculin type delayed hypersensitivity.
Thus B.
cepacia antigens were B and T cells dependent type, and could be a useful immunogen for vaccine development.
American Psychological Association (APA)
Abbas, Ala Fahim& Kadum, Samah Ahmad. 2017. A study of response to Burkholdaria cepacia. al-Kufa University Journal for Biology،Vol. 9, no. 2, pp.55-64.
https://search.emarefa.net/detail/BIM-786585
Modern Language Association (MLA)
Abbas, Ala Fahim& Kadum, Samah Ahmad. A study of response to Burkholdaria cepacia. al-Kufa University Journal for Biology Vol. 9, no. 2 (2017), pp.55-64.
https://search.emarefa.net/detail/BIM-786585
American Medical Association (AMA)
Abbas, Ala Fahim& Kadum, Samah Ahmad. A study of response to Burkholdaria cepacia. al-Kufa University Journal for Biology. 2017. Vol. 9, no. 2, pp.55-64.
https://search.emarefa.net/detail/BIM-786585
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 63-64
Record ID
BIM-786585