Effects of bacterial lipopolysaccharide on serum testosterone level and sperm vitality in mature rats
Joint Authors
Hasan, Abd Allah
Khalil, Atif M.
Yusuf, Muhammad
Ahmad, Hasan
Source
Journal of Veterinary Medical Research
Issue
Vol. 24, Issue 1 (30 Jun. 2017)6 p.
Publisher
Beni-Suef University Faculty of Veterinary Medicine
Publication Date
2017-06-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In the last decades, the light had been shed on the importance of male reproduction and how to protect it from disease conditions and inflammation which may cause infertility.
Accordingly, the mechanism underlying inflammation-mediated infertility must be well clarified.
In the present study, an experimental model of acute inflammation in mature male albino rats was established by intraperitoneal (ip) injection of a single dose of lipopolysaccharides (LPS).
Consequently, basic reproductive parameters were estimated after LPS administration.
Blood samples were collected and assayed for serum testosterone levels.
Semen was also analyzed for live sperm percent.
Testes were removed for histopathological evaluation.
The findings revealed that testosterone level in LPS-treated rats decreased significantly (P<0.05) compared to control rats at 6 and 12 hrs after injection.
Meanwhile, serum testosterone recovered 72 hrs after injection.
Moreover, live sperm percent decreased drastically in LPS-treated rats (P<0.001) compared with control rats at 6 and 12 hrs after LPS injection.
Adverse effects of LPS on sperm vitality at 72 hrs after LPS injection were also found.
Microscopic examination revealed that degenerative changes were observed in LPS-treated rats at 6 and 12 hrs.
Most of histopathological findings returned to normal structure in LPS-treated rats at 72 hrs
American Psychological Association (APA)
Hasan, Abd Allah& Yusuf, Muhammad& Khalil, Atif M.& Ahmad, Hasan. 2017. Effects of bacterial lipopolysaccharide on serum testosterone level and sperm vitality in mature rats. Journal of Veterinary Medical Research،Vol. 24, no. 1.
https://search.emarefa.net/detail/BIM-787868
Modern Language Association (MLA)
Ahmad, Hasan…[et al.]. Effects of bacterial lipopolysaccharide on serum testosterone level and sperm vitality in mature rats. Journal of Veterinary Medical Research Vol. 24, no. 1 (2017).
https://search.emarefa.net/detail/BIM-787868
American Medical Association (AMA)
Hasan, Abd Allah& Yusuf, Muhammad& Khalil, Atif M.& Ahmad, Hasan. Effects of bacterial lipopolysaccharide on serum testosterone level and sperm vitality in mature rats. Journal of Veterinary Medical Research. 2017. Vol. 24, no. 1.
https://search.emarefa.net/detail/BIM-787868
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-787868