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Antioxidant and anticancer activities of aaminophosphonates containing thiadiazole moiety
Joint Authors
Kenawy, al-Rifai
Badr al-Din, Ahmad S.
Khamis, Abir A.
Abd al-Majid, Muhammad A.
Azzam, Muhammad M.
Source
Journal of Saudi Chemical Society
Issue
Vol. 22, Issue 1 (31 Jan. 2018), pp.34-41, 8 p.
Publisher
Publication Date
2018-01-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Abstract EN
In the current study, a-aminophosphonates containing thiadiazole moiety (1–4) was synthesized, characterized and their antioxidant and anticancer activities were carried out.
The compounds (1–4) were synthesized from the reaction of 2-amino-5-methyl-1,3,4-thiadiazole with various aldehydes, triphenylphosphite and mixed valence Cu(I)/Cu(II) inorganic coordination polymer as a catalyst.
The elucidation of compounds structures were carried out using different spectroscopic techniques.
The antioxidant properties were carried out using radical scavenging methods (DPPH) which exhibited excellent scavenging activity particularly with compound 3.
The cytotoxic effects of the five compounds on the human hepato cellular carcinoma (HepG2) and breast adeno carcinoma (MCF7) cell lines were evaluated using MTT assay which revealed the presence of cytotoxic effect with highest activity for compound 3 on HepG2 and compound 1 on MCF7.
This suggests that these five compounds, particularly compounds 1 and 3, have antioxidant and anticancer effect and could be used as novel chemotherapeutic compounds but this needs further in vivo investigation to confirm our in vitro results
American Psychological Association (APA)
Azzam, Muhammad M.& Kenawy, al-Rifai& Badr al-Din, Ahmad S.& Khamis, Abir A.& Abd al-Majid, Muhammad A.. 2018. Antioxidant and anticancer activities of aaminophosphonates containing thiadiazole moiety. Journal of Saudi Chemical Society،Vol. 22, no. 1, pp.34-41.
https://search.emarefa.net/detail/BIM-787937
Modern Language Association (MLA)
Azzam, Muhammad M.…[et al.]. Antioxidant and anticancer activities of aaminophosphonates containing thiadiazole moiety. Journal of Saudi Chemical Society Vol. 22, no. 1 (Jan. 2018), pp.34-41.
https://search.emarefa.net/detail/BIM-787937
American Medical Association (AMA)
Azzam, Muhammad M.& Kenawy, al-Rifai& Badr al-Din, Ahmad S.& Khamis, Abir A.& Abd al-Majid, Muhammad A.. Antioxidant and anticancer activities of aaminophosphonates containing thiadiazole moiety. Journal of Saudi Chemical Society. 2018. Vol. 22, no. 1, pp.34-41.
https://search.emarefa.net/detail/BIM-787937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 40-41
Record ID
BIM-787937