Synthesis and antimicrobial activities of novel quinazolin-4 (3H)-one derivatives containing a 1, 2, 4-triazolo (3, 4-b) (1, 3, 4) thiadiazole moiety
Joint Authors
Lv, Xinyang
Fan, Zhijiang
Bao, Xiaoping
Yang, Lan
Source
Journal of Saudi Chemical Society
Issue
Vol. 22, Issue 1 (31 Jan. 2018), pp.101-109, 9 p.
Publisher
Publication Date
2018-01-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Abstract EN
A series of novel quinazolin-4(3H)-one derivatives (6a–6y) containing a 1,2,4-triazolo [3,4-b][1,3,4]thiadiazole moiety were designed and synthesized, and their structures were fully characterized by 1H NMR, 13C NMR, HRMS and IR spectra.
Among them, the structure of compound 6u was unambiguously confirmed via single crystal X-ray diffraction analysis.
The obtained bioassay results showed that compounds 6h, 6k, 6l and 6y had the EC50 (half-maximal effective concentration) values of 34.8, 28.2, 41.5 and 42.5 lg/mL against the phytopathogenic bacterium Xanthomonas oryzae pv.
oryzae (Xoo), respectively, which were significantly better than commercial bactericide Bismerthiazol (EC50 =95.8 lg/mL).
Additionally, compounds 6a and 6b exhibited the strong inhibition activity against the pathogen Xanthomonas axonopodis pv.
citri (Xac).
American Psychological Association (APA)
Lv, Xinyang& Yang, Lan& Fan, Zhijiang& Bao, Xiaoping. 2018. Synthesis and antimicrobial activities of novel quinazolin-4 (3H)-one derivatives containing a 1, 2, 4-triazolo (3, 4-b) (1, 3, 4) thiadiazole moiety. Journal of Saudi Chemical Society،Vol. 22, no. 1, pp.101-109.
https://search.emarefa.net/detail/BIM-787960
Modern Language Association (MLA)
Lv, Xinyang…[et al.]. Synthesis and antimicrobial activities of novel quinazolin-4 (3H)-one derivatives containing a 1, 2, 4-triazolo (3, 4-b) (1, 3, 4) thiadiazole moiety. Journal of Saudi Chemical Society Vol. 22, no. 1 (Jan. 2018), pp.101-109.
https://search.emarefa.net/detail/BIM-787960
American Medical Association (AMA)
Lv, Xinyang& Yang, Lan& Fan, Zhijiang& Bao, Xiaoping. Synthesis and antimicrobial activities of novel quinazolin-4 (3H)-one derivatives containing a 1, 2, 4-triazolo (3, 4-b) (1, 3, 4) thiadiazole moiety. Journal of Saudi Chemical Society. 2018. Vol. 22, no. 1, pp.101-109.
https://search.emarefa.net/detail/BIM-787960
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 108-109
Record ID
BIM-787960