Study of plasma levels of soluble triggering receptor expressed on myeloid cells-1 in rheumatoid arthritis and its correlation with disease activity and tumor necrosis factor-α

Joint Authors

al-Hiwala, Abd al-Samad I.
Badr, Iman
Aysili, Hibah A.
Abd Allah, Iman A.
Sulayman, Samar G.

Source

Egyptian Rheumatology and Rehabilitation

Issue

Vol. 45, Issue 1 (31 Mar. 2018), pp.18-24, 7 p.

Publisher

The Egyptian Society for Rheumatology and Rehabilitation

Publication Date

2018-03-31

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine

Topics

Abstract EN

Aim of the work The triggering receptor expressed on myeloid cells-1 (TREM-1) is a cell surface receptor expressed mainly on monocytes and neutrophils.

It acts as an amplifier of inflammatory response in acute and chronic inflammatory states.

The aim of this work was to study the plasma-soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in rheumatoid arthritis (RA) patients and its correlation with disease activity and tumor necrosis factor-α (TNF-α).

Patients and methods This study included 80 patients with RA and 20 age-matched and sex-matched controls.

All were subjected to demographic, clinical, laboratory, and radiological studies using the 28-joint Disease Activity Score, erythrocyte sedimentation rate, complete blood count, and radiograph of both hands.

Plasma levels of sTREM-1 and TNF-α were measured with enzyme-linked immunosorbent assay.

Results RA patients had significantly higher sTREM-1 and TNF-a levels compared with controls (206.32±125.75 and 17.83±11.88; P<0.001) and (190.82±69.46 and 54.75±9.46; P<0.001).

In RA patients, sTREM-1 levels were found to be positively correlated with 28-joint Disease Activity Score, erythrocyte sedimentation rate, and TNF-a level (r=0.408, P=0.001; r=0.287, P=0.010; r=0.749, P=0.001).

sTREM-1 level was significantly increasing as patients had increasing disease activity (F-test=20.62; P=0.001).

Conclusion RA patients had higher sTREM-1 and TNF-a level compared with controls, and sTREM-1 level was correlated with disease activity, suggesting that sTREM-1 plays a role in the inflammatory process associated with TNF-a, and it may be a useful disease activity marker in RA.

TREM-1 may be a safe therapeutic strategy for RA, as blocking TREM-1 signaling was found to suppress inflammatory responses without affecting the immune system to fight bacterial infection.

American Psychological Association (APA)

al-Hiwala, Abd al-Samad I.& Sulayman, Samar G.& Badr, Iman& Aysili, Hibah A.& Abd Allah, Iman A.. 2018. Study of plasma levels of soluble triggering receptor expressed on myeloid cells-1 in rheumatoid arthritis and its correlation with disease activity and tumor necrosis factor-α. Egyptian Rheumatology and Rehabilitation،Vol. 45, no. 1, pp.18-24.
https://search.emarefa.net/detail/BIM-789882

Modern Language Association (MLA)

al-Hiwala, Abd al-Samad I.…[et al.]. Study of plasma levels of soluble triggering receptor expressed on myeloid cells-1 in rheumatoid arthritis and its correlation with disease activity and tumor necrosis factor-α. Egyptian Rheumatology and Rehabilitation Vol. 45, no. 1 (Jan. / Mar. 2018), pp.18-24.
https://search.emarefa.net/detail/BIM-789882

American Medical Association (AMA)

al-Hiwala, Abd al-Samad I.& Sulayman, Samar G.& Badr, Iman& Aysili, Hibah A.& Abd Allah, Iman A.. Study of plasma levels of soluble triggering receptor expressed on myeloid cells-1 in rheumatoid arthritis and its correlation with disease activity and tumor necrosis factor-α. Egyptian Rheumatology and Rehabilitation. 2018. Vol. 45, no. 1, pp.18-24.
https://search.emarefa.net/detail/BIM-789882

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 23-24

Record ID

BIM-789882