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Hepatitis B virus-surface gene mutations and their clinical Implications
Joint Authors
Hamad al-Nil, Yasir M.
Bakhit, Sahar
Source
Sudan Journal of Medical Sciences
Issue
Vol. 12, Issue 2 (30 Jun. 2017), pp.101-113, 13 p.
Publisher
Omdurman Islamic University Faculty of Medicine
Publication Date
2017-06-30
Country of Publication
Sudan
No. of Pages
13
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Hepatitis B infection is a major public health problem caused by hepatitis B virus (HBV).
Factors associated with host immunity such as (HBV specific T- and/or Bcell) production and antigen presentation failure and viral determinants such as the HBV genotypes and their evolving variants, have largely contributed to and justified variations that occur in the HBV surface gene.
Hepatitis B surface gene mutations may influence the accuracy of the results obtained with currently used serological diagnostic tests and may represent a great risk for the community, since neither hepatitis B vaccines nor hepatitis B immunoglobulin will prevent the infection by HBV.
Out of 96 published papers from (1988 till 2016) downloaded from Google scholar and PubMed and evaluated according to the relevance of scientific data for the surface gene mutations of hepatitis B virus then52 papers of them were selected and included in this study, then we reviewed and evaluated the current published papers about the surface gene mutations worldwide in which G145R represents the most common hepatitis B surface gene mutation reported in the literature.
Furthermore, we reviewed their clinical implications and their impact on hepatitis B vaccination and treatment.
American Psychological Association (APA)
Hamad al-Nil, Yasir M.& Bakhit, Sahar. 2017. Hepatitis B virus-surface gene mutations and their clinical Implications. Sudan Journal of Medical Sciences،Vol. 12, no. 2, pp.101-113.
https://search.emarefa.net/detail/BIM-790202
Modern Language Association (MLA)
Hamad al-Nil, Yasir M.& Bakhit, Sahar. Hepatitis B virus-surface gene mutations and their clinical Implications. Sudan Journal of Medical Sciences Vol. 12, no. 2 (Jun. 2017), pp.101-113.
https://search.emarefa.net/detail/BIM-790202
American Medical Association (AMA)
Hamad al-Nil, Yasir M.& Bakhit, Sahar. Hepatitis B virus-surface gene mutations and their clinical Implications. Sudan Journal of Medical Sciences. 2017. Vol. 12, no. 2, pp.101-113.
https://search.emarefa.net/detail/BIM-790202
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 109-113
Record ID
BIM-790202