The comparison effect of nickel (II)‎ and cadmium (II)‎ complexes with aqueous extract of tecrium polium L. (Ja, adah)‎ plant on hepatocellular carcinoma cell line HeP2 mium (II)‎ complexes with aqueous extract of tecrium polium L. (Ja,adah)‎ plant on hepatocellular carcinoma cell line HeP2

Abstract EN

Cancer stay to be one of the leading causes of death throughout the world due to a limited success to use treatments.

The new synthesized metal complexes with formula: [Ni L2 (H2O)2].

2.5 E t OH and [Cd L2].

½ H2O Where L = Bis [ 5 – ( P – nitrophenyl ) - 4 – phenyl 1 , 2 , 4 – trazol – 3 – dithiocarbamato hydrazide ] and the aqueous extract of Teucrium polium L.(TP) plant (Ja,adahin Arabic) were examined against growth cells of hepatocellular Carcinoma cell Line ( HeP2 ).

The cytotoxicity assay of cancer cell line was used for determination of inhibition rate with three concentrations; (62.5, 105 and 250 μg /200μl).

The aqueous extract of TP plant induced death of cancer cells by significant elevation of the inhibition rate to 50.03% while the cytotoxic effect of Ni ( II ) complex reached 45.77% and Cadmium (II) was 35.73% at 125μg /200μl.The present study indicates that there are no significant differences between the two new complexes Nickel(II) and Cadmium(II) compared with anticancer drug Cis-pt for all doses