Glucagon-like peptide-1 levels and related parameters in rheumatoid arthritis patients prone to atherosclerosis
Other Title(s)
مستويات الكلوكاكون شبيه الببيتايد-1 و المعاملات ذات الصلة في مرضى التهاب المفاصل الرثوي المعرضين للإصابة بتصلب الشرايين
Joint Authors
Husayn, Tamara Ala
al-Jawdah, Ban Mahmud Shakir
Shafiq, Nurhan Khalid
Source
Ibn al-Haitham Journal for Pure and Applied Science
Issue
Vol. 30, Issue 1 (30 Apr. 2017), pp.107-117, 11 p.
Publisher
University of Baghdad College of Education for Pure Science / Ibn al-Haitham
Publication Date
2017-04-30
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Abstract EN
The study aimed to estimate the role of glucagon-like peptide-1 (GLP-1) and visfatin as a novel pro inflammatory marker in Rheumatoid Arthritis (RA ) according to the activity scores of disease to assess the possibility of introducing glucagon-like peptide-1 and visfatin in the diagnosis and monitoring of RA patients and to found the correlation of visfatin level with GLP-1 and AIP in patients prone to atherosclerosis ,fifty healthy individuals as control group (G1) and fifty rheumatoid arthritis (RA) patients (G2) were enrolled in this study with middle age ranged (30 – 40) years and BMI ≥24 kg/m2.
ESR ,RF, lipid profile, CRP,insulin, visfatin and GLP-1were determined.
Results in table (1) revealed highly significant increase in ESR,RF,TC,TG,LDL,VLDL and AIP level in rheumatoid arthritis (G2) comparing to (G1) while significant decrease noticed in (G2) group comparing to (G1).
Results in table(2) showed highly significant increase in insulin ,CRP, visfatin and GLP-1 level Results in table(3) illustrated correlation relation data and results revealed highly significant ,were r=0.035 for GLP-1 with visfatin for (G1), and highly significant , r= -0.089 for (G2) as shown in figure(1-A) and(1-B), the result also highly significant were r= -0.183 for GLP-1 with CRP for control group and significant ,r= 0.043 for GLP-1 with CRP for RA group as shown in figure(2-A) and(2-B), and significant, r= -0.056 for GLP-1with AIP for G1 and no significant, were r= 0.042 for GLP-1 with AIP for G2 as shown in figure (3-A)and (3-B).
conclusion that summarized from this study is glucagon-like peptide-1 and visfatin plays a role in RA pathogenesis that can be considered marker in RA .
and may be used as a drug in future for RA patients.
American Psychological Association (APA)
Shafiq, Nurhan Khalid& al-Jawdah, Ban Mahmud Shakir& Husayn, Tamara Ala. 2017. Glucagon-like peptide-1 levels and related parameters in rheumatoid arthritis patients prone to atherosclerosis. Ibn al-Haitham Journal for Pure and Applied Science،Vol. 30, no. 1, pp.107-117.
https://search.emarefa.net/detail/BIM-790563
Modern Language Association (MLA)
Shafiq, Nurhan Khalid…[et al.]. Glucagon-like peptide-1 levels and related parameters in rheumatoid arthritis patients prone to atherosclerosis. Ibn al-Haitham Journal for Pure and Applied Science Vol. 30, no. 1 (Apr. 2017), pp.107-117.
https://search.emarefa.net/detail/BIM-790563
American Medical Association (AMA)
Shafiq, Nurhan Khalid& al-Jawdah, Ban Mahmud Shakir& Husayn, Tamara Ala. Glucagon-like peptide-1 levels and related parameters in rheumatoid arthritis patients prone to atherosclerosis. Ibn al-Haitham Journal for Pure and Applied Science. 2017. Vol. 30, no. 1, pp.107-117.
https://search.emarefa.net/detail/BIM-790563
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 114-116
Record ID
BIM-790563