استعمال أطياف المشتقة الثالثة و الرابعة في التقدير الآني لعقاري الأولانزابين و هيدروكلوريد الأفدرين في بعض أشكالهما النقية و الصيدلانية

Abstract EN

Two new simultaneous spectrophotometric methods for determination of Olanzapine and Ephedrine depend on third (D3) and fourth (D4) derivative of zero spectrum of two drugs were developed.

The peak – to- base line, peak to peak and area under peak were found proportional with concentration of the drugs up to (4-24 µg/ml-1) at known experimental wavelengths.

The results showed that the method was precise and accurate through RSD% (0.5026-4.0273),( 0.2399 -6.9888) and R.E% (-2.3889-0.8333) , )-2.9444-0.2273) while the LOD (0.0057- 0.8510 μg.ml-1), ( 0.0953-0.9844 μg.ml-1) and LOQ (0.0173- 2.5788μg.ml-1),( 0.5774-2.9829 μg.ml-1) were found for the two drugs respectively.

The methods were applied ide to the determination of Olanzapine and Ephedrine in pharmaceutical preparations successfully.