Docetaxel chemotherapy induced peripheral neuropathy in breast cancer patients and its amelioration by vitamin E
Joint Authors
Farhan, Adil Hamid
Hamid, Haydar Yusuf
Kammunah, Talib Husayn
Muhammad, Ammar Rasul
Source
Issue
Vol. 17, Issue 1 (30 Jun. 2014), pp.13-27, 15 p.
Publisher
University of Kufa Faculty of Medicine
Publication Date
2014-06-30
Country of Publication
Iraq
No. of Pages
15
Main Subjects
Abstract EN
Background: Chemotherapy is used to treat different types of cancer.
Its use is associated with neurotoxicity, the most common of them is peripheral neuropathy.
Taxanes are recognized to cause peripheral neuropathy of which Docetaxel is studied.
Aim: To evaluate the neurotoxicity of Docetaxel and assess the protective effect of vitamin E in breast cancer patients.
Methods: In a prospective placebo controlled randomized study, 60 women with breast cancer were selected.
Patients had surgery and planned for chemotherapy administration.
Chemotherapy protocol used is TAC that includes Docetaxel, Doxorubicin and Cyclophosphamide given every 21 days.
They are assessed for neuropathy clinically and by nerve conduction study at the baseline and after completion of chemotherapy.
They are divided into 2 groups each composed of 30 patients.
The 1st group is given Vitamin E and the second group is given placebo.
Results: showed that the incidence of neuropathy is the same in both groups, but it was less severe in Vitamin E treated group compared to the placebo group.
Conclusion: vitamin E ameliorates the severity of peripheral neuropathy and can be used for this purpose.
Recommendation: We recommend large multicenter studies to be done and using other agents that possibly prevent or ameliorate Docetaxel induced neuropathy in the future.
American Psychological Association (APA)
Kammunah, Talib Husayn& Hamid, Haydar Yusuf& Muhammad, Ammar Rasul& Farhan, Adil Hamid. 2014. Docetaxel chemotherapy induced peripheral neuropathy in breast cancer patients and its amelioration by vitamin E. Kufa Medical Journal،Vol. 17, no. 1, pp.13-27.
https://search.emarefa.net/detail/BIM-790711
Modern Language Association (MLA)
Farhan, Adil Hamid…[et al.]. Docetaxel chemotherapy induced peripheral neuropathy in breast cancer patients and its amelioration by vitamin E. Kufa Medical Journal Vol. 17, no. 1 (2014), pp.13-27.
https://search.emarefa.net/detail/BIM-790711
American Medical Association (AMA)
Kammunah, Talib Husayn& Hamid, Haydar Yusuf& Muhammad, Ammar Rasul& Farhan, Adil Hamid. Docetaxel chemotherapy induced peripheral neuropathy in breast cancer patients and its amelioration by vitamin E. Kufa Medical Journal. 2014. Vol. 17, no. 1, pp.13-27.
https://search.emarefa.net/detail/BIM-790711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 25-27
Record ID
BIM-790711