The effect of gallic acid as protective agent on some biochemical parameters induced hypercholesterolemia in laboratory male rats

Abstract EN

The role of gallic acid was studied to alleviating some biochemical parameters alterations in hyper cholesterolemia in rats.

For this purpose 24 sexually adult male rats were divided randomly in to 4 groups (6 rats each).

The experiment was conducted at the animal house of the Veterinary Medicine College–University of Basrah, the control group, rats were injected intraperitoneally ( I.P.) with 0.9 % normal saline (N.S)and were supply with the stander ration.

The first treated group were injected intraperitoneally ( I.P.) with 100 mg/ kg gallic acid dissolve in 0.5 ml distilled water daily and were supply with the stander ration.

The second treated group were supplied with the stander ration in addition to 1.5% cholesterol of the stander ration .

The third treated group were supplied with standard ration in addition to 1.5% cholesterol, and injected intraperitoneally ( I.P.) after one hour with 100 mg/kg gallic acid dissolved in 0.5 ml distilled water The obtained results indicated that the administration gallic acid as protective agent on high cholesterol diet tend to alleviated and improved lipid profile by a significant reduction in the serum total cholesterol (TC),LDL-C and VLDL compared with animals fed cholesterol 1,5 % diet, hepatic enzymes activates of AST &ALT in the protective group almost were at the range of normal values and the protective urea blood value reach almost as the normal level as control group.