Acid folic supplementation in major depressive disorder treatment : a double-blind randomized clinical trial
Joint Authors
Gholampoor, Narjis
Sepehrmanesh, Zahrah
Omidi, Abd Allah
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 19, Issue 2 (28 Feb. 2017), pp.1-8, 8 p.
Publisher
Publication Date
2017-02-28
Country of Publication
United Arab Emirates
No. of Pages
8
Main Subjects
Abstract EN
Background: Augmentation therapy involves the addition of a second drug, such as mood stabilizers, antipsychotics, and nutritional supplements, to a primary antidepressant treatment.
Studies on adding folic acid to a preexisting antidepressive regimen as a form of augmentation therapy have had different and even controversial results.
Objectives: This study aimed to determine the effects that adding folic acid to a pharmaceutical diet with citalopram has on the treatment of depression.
Methods: This double-blind randomized clinical trial was conducted in Kashan, Iran on 90 patients who suffered from depression.
Patients were allocated to study groups using random permuted blocks.
One group (n = 45) received a dosage of 20 mg citalopram in combination with 2.5mgfolic acid on a daily basis, and the other group (n = 45) received the same daily dose of citalopram with a placebo for eight weeks.
To measure the severity of each patient’s depression, the Beck depression inventory II (BDI-II) questionnaire was used prior to starting the antidepressant therapy and was repeated four, six, and eight weeks after beginning the treatment.
A reduction from the original BDI-II scores that was greater than 50% was considered to be a response to treatment.
Results: The average depression scores before treatment were 30.111.41 in the intervention group and 31.241.26 in the control group (P = 0.6).
At the end of the study, the depression scores in the intervention and the control groups were 13.31 57 and 19.11 8.95espectively (P < 0.001).
A reduction in the average depression scores of the intervention group was statistically significant after six and eight weeks (P = 0.01 and P = 0.001, respectively).
At the end of the study, the frequency of response to treatment was 73.3% in the intervention group and 40.0% in the control group (P < 0.001).
Conclusions: Folic acid, when used as a complementary therapy, can improve a patient’s response to antidepressants used for the treatment of major depression.
American Psychological Association (APA)
Sepehrmanesh, Zahrah& Omidi, Abd Allah& Gholampoor, Narjis. 2017. Acid folic supplementation in major depressive disorder treatment : a double-blind randomized clinical trial. Iranian Red Crescent Medical Journal،Vol. 19, no. 2, pp.1-8.
https://search.emarefa.net/detail/BIM-791791
Modern Language Association (MLA)
Sepehrmanesh, Zahrah…[et al.]. Acid folic supplementation in major depressive disorder treatment : a double-blind randomized clinical trial. Iranian Red Crescent Medical Journal Vol. 19, no. 2 (Feb. 2017), pp.1-8.
https://search.emarefa.net/detail/BIM-791791
American Medical Association (AMA)
Sepehrmanesh, Zahrah& Omidi, Abd Allah& Gholampoor, Narjis. Acid folic supplementation in major depressive disorder treatment : a double-blind randomized clinical trial. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 2, pp.1-8.
https://search.emarefa.net/detail/BIM-791791
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6-8
Record ID
BIM-791791