Discrimination between drug abuse and medical therapy : case report of a tranylcypromine overdose-related fatality
Other Title(s)
التمييز بين تعاطي المخدرات و العلاج الدوائي : تقرير حالة عن وفاة ذات صلة باستعمال جرعة زائدة لعقار الترانيلسيبرومين
Joint Authors
Akhgari, Maryam
Jokar, Farzaneh
Itimadi Aleagha, Afshar
Qasimi, Ali
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 17, Issue 2 (30 May. 2017), pp.312-317, 6 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2017-05-30
Country of Publication
Oman
No. of Pages
6
Main Subjects
Topics
Abstract EN
Tranylcypromine is an effective antidepressant from the class of monoamine oxidase inhibitors and is structurally related to amphetamine.
However, reports differ regarding the potential metabolism of tranylcypromine to amphetamine and methamphetamine within the human body.
We report a 25-year-old woman with severe depression who died due to a fatal tranylcypromine overdose in 2016.
She had been prescribed tranylcypromine one day previously and had no history of previous suicide attempts or substance abuse.
The body was transferred to a forensic medicine department in Tehran, Iran for the autopsy.
A urine sample was positive for tranylcypromine, amphetamine and methamphetamine using gas chromatography/mass spectrometry after derivatisation with heptafluorobutyric acid.
As amphetamines were present in the urine sample, it was assumed that the tranylcypromine had been converted to amphetamines metabolically.
As such, it is possible that the legitimate use of certain prescription drugs may complicate the interpretation of test results for illegal drugs
American Psychological Association (APA)
Akhgari, Maryam& Jokar, Farzaneh& Itimadi Aleagha, Afshar& Qasimi, Ali. 2017. Discrimination between drug abuse and medical therapy : case report of a tranylcypromine overdose-related fatality. Sultan Qaboos University Medical Journal،Vol. 17, no. 2, pp.312-317.
https://search.emarefa.net/detail/BIM-791818
Modern Language Association (MLA)
Akhgari, Maryam…[et al.]. Discrimination between drug abuse and medical therapy : case report of a tranylcypromine overdose-related fatality. Sultan Qaboos University Medical Journal Vol. 17, no. 2 (May. 2017), pp.312-317.
https://search.emarefa.net/detail/BIM-791818
American Medical Association (AMA)
Akhgari, Maryam& Jokar, Farzaneh& Itimadi Aleagha, Afshar& Qasimi, Ali. Discrimination between drug abuse and medical therapy : case report of a tranylcypromine overdose-related fatality. Sultan Qaboos University Medical Journal. 2017. Vol. 17, no. 2, pp.312-317.
https://search.emarefa.net/detail/BIM-791818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 216-217
Record ID
BIM-791818