Delayed treatment response in a neonate with multisystem langerhans cell histiocytosis : case report and review of literature
Other Title(s)
الاستجابة المتأخرة للعلاج في طفل حديث الولادة مصاب بمرض لانجرهانز هيستيوسيتوزيس : تقرير حالة و مراجعة اللأدبيات
Joint Authors
Singh, Lavleen
Singh, Amitabh
Mandal, Anirban
Mishra, Sataroopa
Patel, Ankita
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 17, Issue 2 (30 May. 2017), pp.205-228, 24 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2017-05-30
Country of Publication
Oman
No. of Pages
24
Main Subjects
Topics
Abstract EN
Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of the Langerhans cells, which are part of the mononuclear phagocytic system.
The disorder varies in terms of the extent of the disease, its natural course and patient outcomes.
While skin rashes are a common presentation of neonatal LCH, other systems or organs may also be involved.
Delays in the diagnosis of neonatal LCH may occur due to its non-specific presentation and a lack of awareness of the condition among doctors.
We report a two-month-old male neonate who presented to the Chacha Nehru Bal Chikitsalya hospital, New Delhi, India, in 2016 after the onset of pulmonary symptoms. He had been noted to have a generalised rash which had progressively worsened from 15 days of age.
Following a skin biopsy and chest imaging, he was diagnosed with multisystem LCH with risk organ involvement.
There was a delayed response to combined chemotherapy with no major side-effects
American Psychological Association (APA)
Singh, Amitabh& Mandal, Anirban& Singh, Lavleen& Mishra, Sataroopa& Patel, Ankita. 2017. Delayed treatment response in a neonate with multisystem langerhans cell histiocytosis : case report and review of literature. Sultan Qaboos University Medical Journal،Vol. 17, no. 2, pp.205-228.
https://search.emarefa.net/detail/BIM-791821
Modern Language Association (MLA)
Singh, Amitabh…[et al.]. Delayed treatment response in a neonate with multisystem langerhans cell histiocytosis : case report and review of literature. Sultan Qaboos University Medical Journal Vol. 17, no. 2 (May. 2017), pp.205-228.
https://search.emarefa.net/detail/BIM-791821
American Medical Association (AMA)
Singh, Amitabh& Mandal, Anirban& Singh, Lavleen& Mishra, Sataroopa& Patel, Ankita. Delayed treatment response in a neonate with multisystem langerhans cell histiocytosis : case report and review of literature. Sultan Qaboos University Medical Journal. 2017. Vol. 17, no. 2, pp.205-228.
https://search.emarefa.net/detail/BIM-791821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 228
Record ID
BIM-791821