Association between omeprazole use and clostridium difficile infection among hospitalized patients : a case-control study of the Saudi population
Joint Authors
Ahmad, Anwar E.
al-Utaybi, Hazza
al-Umari, Maha
Source
Issue
Vol. 2017, Issue 2 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Publication Date
2017-12-31
Country of Publication
Qatar
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background: While few international studies have assessed the association between omeprazole use and the risk of Clostridium difficile infection (CDI), research into this is lacking in Saudi Arabia and the Middle East region.
The aim of this study was to determine whether exposure to omeprazole is associated with the risk of Clostridium difficile infection in a sample of hospitalized Saudi patients.
Methodology: A retrospective matched case–control study was conducted at the King Abdulaziz Medical City in Riyadh, Saudi Arabia, from 1 August 2010 through 31 July 2015.
The analysis included a total of 200 patients: 100 CDI cases and 100 matched controls.
Results: The majority (60%, 120 out of 200) of patients had received proton pump inhibitors (PPIs), and a minority (18.5%, 37 out of 200) had received omeprazole.
The PPI use was insignificantly higher in CDI cases than in controls.
However, the use of omeprazole was significantly higher in CDI cases compared with controls.
Specifically, patients receiving omeprazole were two times more likely to develop CDI compared with controls (aOR ¼ 2.1, 95% confidence interval (CI) ¼ (1.007–4.437)).
After adjusting for potential predictors of CDI, watery diarrhea (aOR ¼ 59.1, 95% CI ¼ 19.831–175.974) and abdominal pain (aOR ¼ 7.5, 95% CI ¼ 2.184– 25.445) were found to be independent predictors of CDI.
Conclusions: The data suggests that PPIs were commonly used in patients admitted to King Abdulaziz Medical City in Riyadh: six out of ten patients received PPIs.
The findings support a possible association between the use of omeprazole and a high risk of CDI.
To confirm causality, the link between omeprazole and CDI should be assessed in a large interventional study
American Psychological Association (APA)
al-Utaybi, Hazza& al-Umari, Maha& Ahmad, Anwar E.. 2017. Association between omeprazole use and clostridium difficile infection among hospitalized patients : a case-control study of the Saudi population. Qatar Medical Journal،Vol. 2017, no. 2, pp.1-7.
https://search.emarefa.net/detail/BIM-791997
Modern Language Association (MLA)
al-Utaybi, Hazza…[et al.]. Association between omeprazole use and clostridium difficile infection among hospitalized patients : a case-control study of the Saudi population. Qatar Medical Journal No. 2 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-791997
American Medical Association (AMA)
al-Utaybi, Hazza& al-Umari, Maha& Ahmad, Anwar E.. Association between omeprazole use and clostridium difficile infection among hospitalized patients : a case-control study of the Saudi population. Qatar Medical Journal. 2017. Vol. 2017, no. 2, pp.1-7.
https://search.emarefa.net/detail/BIM-791997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6-7
Record ID
BIM-791997