حركية الباراسيتامول في أفراخ الدجاج المعاملة بالمترونيدازول
Other Title(s)
Pharmacokinetics of paracetamol in chicks treated with metronidazole
Author
Source
المجلة العراقية للعلوم البيطرية
Issue
Vol. 31, Issue 1 (30 Jun. 2017), pp.25-29, 5 p.
Publisher
University of Mosul College of Veterinary Medicine
Publication Date
2017-06-30
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Effect of metronidazole on the pharmacokinetics of paracetamol were examined in chicks.
Chicks were dosed orally with metronidazole at 350 mg\kg of body weight daily (10 -13 days of age).
On the last day of metronidazole dosing, chicks injected intraperitoneally with paracetamol at of 50 mg\kg of body weight.
Paracetamol appeared in chick plasma at 52.00, 45.00, 40.75, 32.75, 23.25 μg \ml after 0.25, 0.50, 0.75, 1, 2, 4 hours of injection respectively.
A significantly decreased the concentration paracetamol at times of 0.25, 0.50, 0.75, 1, 4 hours post injection and appeared at concentrations of 36.62, 35.37, 25.62, 20.50, 11.00 μg\ml.
These was reflected by changes in the pharmacokinetics of paracetamol as show by the increase elimination rate constant (48%) and decrease in the half-life (32 %) and increase in volume distribution (29%) and increase in clearance by (96%) and decrease in the area under the plasma curve (33%) and decrease in the area under moment curve 65% and lack mean residence time (33%).
These results indicate that oral dosing of chicks with metronidazole for four consecutive days and this effect increase in the elemination rate of paracetamol and this effect must be considered when therapy with paracetamol when given during metronidazole therapy.
American Psychological Association (APA)
حسين، سوسن محمد أمين. 2017. حركية الباراسيتامول في أفراخ الدجاج المعاملة بالمترونيدازول. المجلة العراقية للعلوم البيطرية،مج. 31، ع. 1، ص ص. 25-29.
https://search.emarefa.net/detail/BIM-792222
Modern Language Association (MLA)
حسين، سوسن محمد أمين. حركية الباراسيتامول في أفراخ الدجاج المعاملة بالمترونيدازول. المجلة العراقية للعلوم البيطرية مج. 31، ع. 1 (2017)، ص ص. 25-29.
https://search.emarefa.net/detail/BIM-792222
American Medical Association (AMA)
حسين، سوسن محمد أمين. حركية الباراسيتامول في أفراخ الدجاج المعاملة بالمترونيدازول. المجلة العراقية للعلوم البيطرية. 2017. مج. 31، ع. 1، ص ص. 25-29.
https://search.emarefa.net/detail/BIM-792222
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية : ص. 28-29
Record ID
BIM-792222