The role of quercetin in gene expression of glur1 subunit of ampa receptors, and nr2a and nr2b subunits of nmda receptors in kainic acid model of seizure in mice
Joint Authors
Moghbelinejad, Sahar
Muhammadi, Ghazalah
Khodabandehloo, Fatimah
Nasirpour, Taghi
Rashvand, Zahrah
Nasiri Asl, Murjan
Najafipour, Rida
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 19, Issue 5 (31 May. 2017), pp.1-5, 5 p.
Publisher
Publication Date
2017-05-31
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background: Flavonoids are recently being recognized for their important biological effects.
Quercetin is a flavonoid that has several pharmacological properties including anti-inflammatory, neuroprotective, and anticonvulsant effects.
Objectives: This study was designed to elucidate the role of quercetin in the gene expression of ionotropic glutamate receptor subunits in kainic acid (KA)-induced seizure in mice.
Methods: This experimental study was conducted on 56 male BALB/c mice.
Quercetin (50 and 100 mg/kg, intraperitoneally) was administered 7 days before administration of KA.
The hippocampi of the animals were removed and used for molecular analysis 2 hours and 7 days after KA administration.
Results: Pretreatment of mice with quercetin (100 mg/kg) significantly enhanced the gene expression of GluR1 subunit of AMPA and NR2A and NR2B subunits of NMDA only 7 days after KA administration compared to the control and KA groups in the mice hippocampus (P < 0.001, P < 0.001, and P < 0.05, respectively).
Conclusions: Increment of gene expression of subunits of AMPA and NMDA receptors by quercetin might explain its protective effect on synaptic plasticity and memory.
American Psychological Association (APA)
Moghbelinejad, Sahar& Muhammadi, Ghazalah& Khodabandehloo, Fatimah& Najafipour, Rida& Nasirpour, Taghi& Rashvand, Zahrah…[et al.]. 2017. The role of quercetin in gene expression of glur1 subunit of ampa receptors, and nr2a and nr2b subunits of nmda receptors in kainic acid model of seizure in mice. Iranian Red Crescent Medical Journal،Vol. 19, no. 5, pp.1-5.
https://search.emarefa.net/detail/BIM-793200
Modern Language Association (MLA)
Najafipour, Rida…[et al.]. The role of quercetin in gene expression of glur1 subunit of ampa receptors, and nr2a and nr2b subunits of nmda receptors in kainic acid model of seizure in mice. Iranian Red Crescent Medical Journal Vol. 19, no. 5 (May. 2017), pp.1-5.
https://search.emarefa.net/detail/BIM-793200
American Medical Association (AMA)
Moghbelinejad, Sahar& Muhammadi, Ghazalah& Khodabandehloo, Fatimah& Najafipour, Rida& Nasirpour, Taghi& Rashvand, Zahrah…[et al.]. The role of quercetin in gene expression of glur1 subunit of ampa receptors, and nr2a and nr2b subunits of nmda receptors in kainic acid model of seizure in mice. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 5, pp.1-5.
https://search.emarefa.net/detail/BIM-793200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 4-5
Record ID
BIM-793200