Synthesis, supramolecularity and bioactivity of new calix [4] arene lattice host molecules

Other Title(s)

التحضير و التشخيص و التركيب البلوري و النشاط الحيوي لمركبات جديدة من مشتقات كاليكس [4] ارينريسورسينول

Dissertant

al-Sarhan, Sad

Thesis advisor

al-Shahatit, Sulhi F.

University

Mutah University

Faculty

Faculty of Science

Department

Department of Chemistry

University Country

Jordan

Degree

Master

Degree Date

2012

English Abstract

This thesis is concerned with the preparation and characterization of new calix[4]arene derivatives through acid catalyzed condensation of resorcinol with the p-substituted benzaldehyde such as: p - chlorobenzaldehyde, p -bromobenzaldehyde, p -fluorobenzaldehyde, and p - methoxybenzaldehyde.

The new Calix[4]arene were characterized by melting points, FTIR, 1H-NMR and 13C-NMR.

They inhibit the growth of gram positive bacteria with brominated derivative being the most potent agent (MIC) (15.6-125 μg/ml).

In addition, the solid state structure of the inclusion compounds 49 and 51 have been determined by single-crystal Xray diffraction.

The inter- and intra- molecular noncovalent supramolecular interactions involved in the crystal structure of these compounds have been carefully investigated and presented in terms of crystal engineering and supramolecular chemistry

Main Subjects

Chemistry

No. of Pages

59

Table of Contents

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Language

English

Data Type

Arab Theses

Record ID

BIM-793433