Study the effect of tamoxifenon lipid profile in male albino rats

Abstract EN

Tamoxifen(TAM) is an effective anticancer drug.

This study was conducted to evaluate the side effects of Tamoxifenon the lipid profile.

40 rats divided into 4 equal groups,3 groups were given different doses (30, 40, 50)mg/kg body weight of TAM three times a week for 8 weeks as well as control group that was given with physiological solution.At the end ofexperiment, The results showed significant differences in the treated groups were the results showed a significant degrees (p<0.05) in the HDL level in the treatment group (50mg/kg) while the three groups showed a significant increase in the levels of (Ch, TG, LDL, VLDL).

The results of the study showed that Tamoxifen caused an accumulation in fats.