Effects of saffron aqueous extract and its main constituent, crocin, on health-related quality of life, depression, and sexual desire in coronary artery disease patients : a double-blind, placebo-controlled randomized clinical trial
Joint Authors
Ostadrahimi, Ali Rida
Abedimanesh, Nasim
Bathaie, S. Zahra
Abedimanesh, Said
Motlagh, Behrooz
Sadeghi, Muhammad Rida Taban
Jafar Abbadi, Muhammad Asghari
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 19, Issue 9 (30 Sep. 2017), pp.1-8, 8 p.
Publisher
Publication Date
2017-09-30
Country of Publication
United Arab Emirates
No. of Pages
8
Main Subjects
Abstract EN
Background : Depression and sexual problems are common in patients with coronary artery disease (CAD) and can influence their quality of life.
Objectives : The aim of this study was to compare the efficacy of saffron and its main constituent, crocin, in improving mental and sexual health and ultimately quality of life in CAD patients.
Methods : This double-blind, placebo-controlled, randomized clinical trial was carried out during 8 weeks in 3 groups, including 1 placebo and 2 intervention groups.
The study sample included 58 CAD patients within the age range of 40 - 65 years, referred to Shahid Madani cardiovascular hospital, Tabriz, Iran, from April 2015 to November 2016.
The intervention groups received saffron aqueous extract (SAE; 30 mg; n, 20) or crocin (30 mg; n, 19).
All the groups completed the demographic questionnaire, Beck depression inventory-II (BDI-II), Hulbert index of sexual desire (HISD), and MacNew health-related quality of life questionnaire.
Results: The BDI-II score significantly decreased in the SAE (pre- and post test scores, 26.10 11.98 and 21.05 9.93, respectively) and crocin (pre- and post test scores, 27.898.46 and 22.688.01, respectively) groups (P < 0.001).
After adjustments for age, sex, and diagnosis time, similar results were obtained.
There was no significant difference between the crocin and SAE groups in terms of total BDI-II score at the end of the study (P = 0.999).
SAE and crocin had no significant effects on HISD scores (P = 0.148 and 0.317, respectively).
However, they could significantly improve the total quality of life and its subscales (P < 0.001).
Conclusions : SAE and crocin could improve depression and health-related quality of life in patients with CAD, whereas they had no significant effects on sexual desire.
American Psychological Association (APA)
Abedimanesh, Nasim& Ostadrahimi, Ali Rida& Bathaie, S. Zahra& Abedimanesh, Said& Motlagh, Behrooz& Jafar Abbadi, Muhammad Asghari…[et al.]. 2017. Effects of saffron aqueous extract and its main constituent, crocin, on health-related quality of life, depression, and sexual desire in coronary artery disease patients : a double-blind, placebo-controlled randomized clinical trial. Iranian Red Crescent Medical Journal،Vol. 19, no. 9, pp.1-8.
https://search.emarefa.net/detail/BIM-796199
Modern Language Association (MLA)
Abedimanesh, Nasim…[et al.]. Effects of saffron aqueous extract and its main constituent, crocin, on health-related quality of life, depression, and sexual desire in coronary artery disease patients : a double-blind, placebo-controlled randomized clinical trial. Iranian Red Crescent Medical Journal Vol. 19, no. 9 (Sep. 2017), pp.1-8.
https://search.emarefa.net/detail/BIM-796199
American Medical Association (AMA)
Abedimanesh, Nasim& Ostadrahimi, Ali Rida& Bathaie, S. Zahra& Abedimanesh, Said& Motlagh, Behrooz& Jafar Abbadi, Muhammad Asghari…[et al.]. Effects of saffron aqueous extract and its main constituent, crocin, on health-related quality of life, depression, and sexual desire in coronary artery disease patients : a double-blind, placebo-controlled randomized clinical trial. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 9, pp.1-8.
https://search.emarefa.net/detail/BIM-796199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-8
Record ID
BIM-796199