Fluoxetine potentiate the analgesic effect of diclofenac in male mice
Other Title(s)
الفلوكسيتين يقوي تأثير الدايكلوفيناك كمسكن للألم في ذكور الفئران
Author
Source
Issue
Vol. 14, Issue 3 (30 Sep. 2017), pp.436-441, 6 p.
Publisher
University of Babylon College of Medicine
Publication Date
2017-09-30
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Fluoxetine is a selective serotonin re-uptake inhibitors (SSRI) drug, which is the most widely used in the treatment of depression.
The aims of this study were to evaluate the analgesic effects of fluoxetine, and the analgesic effect of combination of fluoxetine and diclofenac in model of thermal pain in male mice.
Mice were divided into four groups, six in each.
Group 1 received normal saline.
Group 2received diclofenac.
Group 3 received fluoxetine.
Group 4 received fluoxetine before the administration of diclofenac.
Evaluation of the analgesic action of the drug was achieved by the tail flick test.
Tail-flick latency significantly increased (P < 0.05) in the group 2 in the 2 time intervals as compared to control group.
In the group 3, there were no significant changes (P > 0.05) in the tail-flick latency after 30 min as compared to corresponding time of control group, while it significantly increased (P < 0.05) after 60 min as compared to corresponding time of control group.
In the group 4caused significant increase (P < 0.05) in the time of tail-flick latency after 60 min as compared to corresponding time of diclofenac group and fluoxetine group.
In this study, combination of low dose diclofenac with fluoxetine caused a significant prolongation of tail-flick latency proposing additive antinociceptive effect.
Thus, combination of diclofenac with fluoxetine hypothetically reduce the dose requirement and adverse effects for each drug..
Further clinical studies are needed to prove these effects.
American Psychological Association (APA)
Salman, Salman Muhammad. 2017. Fluoxetine potentiate the analgesic effect of diclofenac in male mice. Medical Journal of Babylon،Vol. 14, no. 3, pp.436-441.
https://search.emarefa.net/detail/BIM-796279
Modern Language Association (MLA)
Salman, Salman Muhammad. Fluoxetine potentiate the analgesic effect of diclofenac in male mice. Medical Journal of Babylon Vol. 14, no. 3 (2017), pp.436-441.
https://search.emarefa.net/detail/BIM-796279
American Medical Association (AMA)
Salman, Salman Muhammad. Fluoxetine potentiate the analgesic effect of diclofenac in male mice. Medical Journal of Babylon. 2017. Vol. 14, no. 3, pp.436-441.
https://search.emarefa.net/detail/BIM-796279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 440-441
Record ID
BIM-796279