Clinicopathological comparison of fibrous dysplasia and ossifying fibroma

Abstract EN

Fibrous dysplasia and Ossifying fibroma of jawbones share the conduct of similar clinicopathological characteristics and this can be a challenge for the histopathologists.

The purpose of this study was to evaluate the differences in clinicohistopathological features in fibrous dysplasia cells compared with ossifying fibroma of jaws bones.

The study included 30 formalin-fixed, paraffin embedded tissue blocks; of which fifteen for patients with fibrous dysplasia and fifteen sample of ossifying fibroma of jaws.

The histopathological examination was conducted on 4µm thick of H & E tissue sections.

Results: showed where most cases were females; 11 cases (73.3%) for fibrous dysplasia, as well as ossifying fibroma.

Most of FD cases presented in the maxilla (66.76%) while for OF most ofthe cases presented in the mandible (73.33%).

FD cases were more predominant in molar area (60%) whereas OF cases were more predominant in premolar & molar area(33.33%).

Regarding the histopathological components, in all cases of FD (100%) the presence of bone trabecule with large osteocytes within the lacunae was found, while OF featured more irregular osteoid or cementoid masses( 80%) compared to ( 33.3%) osteoid observed in FD.

Remarkable, (80%) of the OF cases had osteoblastic rimming , while it is presented in only two cases ( 13.3%) of total FD sample.

However further studies are required to investigated other features for differentiation.

Although several clinicopathological features can separate FD from OF, it is still difficult to arrive at a definitive diagnosis by using a single diagnostic modality.