The role of proinflammatory cytokines and some hormones in endometriosis-induced osteoporosis

Abstract EN

Objective: The aim of this study is to evaluate the effects of proinflammatory cytokines and some hormones, in patients with endometriosis, on the serum levels of bone formation and bone resorption markers.

Subjects and methods: Eightyfemale patients with endometriosis at their reproductive age subjected to standard criteria were participated in this study.

Eighty apparently healthy women were selected to be a normal group for comparison.

In addition, assessing the serum levels of tumor necrosis factor alpha [TNF-α], interleukin 1[IL-1], interleukin 6 [IL-6], CarboxyterminalTelopeptides of type I Collagen [CTX1], CarboxyterminalPropeptide of type I Procollagen [PICP], Estradiol [E2], Follicle-Stimulating Hormone [FSH], Thyroid-Stimulating Hormone [TSH], and Parathyroid Hormone [PTH] by EILISA and enzymatic Kits.

Results: The results show that the levels of tumor necrosis factor alpha [TNF-α], interleukin 1[IL-1] , interleukin 6[IL-6], C terminal Telopeptides of type I Collagen[CTX1]and C terminal propeptide of type I procollagen[PICP], follicle-stimulating hormone [FSH], thyroid-stimulating hormone [TSH] and parathyroid hormone [PTH] weresignificantly changed in serum of patients with endometriosisas compared with control healthy group.

Whereas, the change of serum estradiol [E2] level was non-significant as compared with control group.

Conclusions: The inflammatory activity of tumor necrosis factor alpha [TNF-α], interleukin 1[IL-1] and interleukin 6 [IL-6] was important in the development of osteoporosis in patients with endometriosisby its effect on bone formation and resorption markers.The role of some hormones, follicle-stimulating hormone [FSH], thyroid-stimulating hormone [TSH] and parathyroid hormone [PTH], in the development of osteoporosis in patients with endometriosis was also assessed.