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Basal cell markers : 34BE12 and p63, improving detection of basal cells in atypical prostatic lesions
Joint Authors
Rashid, Inas A.
Husayn, Ala Ghani
Source
al-Kindy College Medical Journal
Issue
Vol. 13, Issue 2 (31 Dec. 2017), pp.60-63, 4 p.
Publisher
University of Baghdad al-Kindi College of Medicine
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
4
Main Subjects
Abstract EN
Background: The diagnosis of prostatic pathology may be of challenging , as some difficult and suspected, atypical cases may lack basal cell layer by routine H&E sections .
Antibodies against 34BE12(HMW-CK) and p63 aid the diagnosis of such cases , to distinguish benign from malignant prostatic lesions.
Objective: to identify basal cells in atypical prostatic lesions ,and distinguish benign from malignant prostatic lesions.
Type of the study: A retro-spective study.
Methods: 115cases of paraffin embedded prostatic tissue blocks ,diagnosed as : 76 cases were benign prostatic hyperplasia( BPH) , 9 cases were high grade –prostatic intraepithelial neoplasia (HG-PIN) , and 30 cases were prostatic carcinoma(PCa) .Sections from each blocks were prepared for immunostaining with 34BE12 and p63.
Results : basal cells were detected in cases of BPH , and HG-PIN , and absent in all cases of prostatic carcinoma ,using basal cell markers .
Negative benign glands(>2) were found in 71.6% and 38.2% for BPH and 57.1% and 55.6% for HG-PIN immunostained with high molecular weight cytokeratin (34BE12) and p63 , respectively, and significantly reduced to 9.0% and 11.1% for BPH and HG-PIN, respectively with combined using of both markers .Conclusion : Combination of both basal cell markers (34BE12 , p63) improving basal cell detection in atypical ,suspected prostatic lesions and distinguish benign from malignant lesions.
American Psychological Association (APA)
Rashid, Inas A.& Husayn, Ala Ghani. 2017. Basal cell markers : 34BE12 and p63, improving detection of basal cells in atypical prostatic lesions. al-Kindy College Medical Journal،Vol. 13, no. 2, pp.60-63.
https://search.emarefa.net/detail/BIM-796452
Modern Language Association (MLA)
Rashid, Inas A.& Husayn, Ala Ghani. Basal cell markers : 34BE12 and p63, improving detection of basal cells in atypical prostatic lesions. al-Kindy College Medical Journal Vol. 13, no. 2 (2017), pp.60-63.
https://search.emarefa.net/detail/BIM-796452
American Medical Association (AMA)
Rashid, Inas A.& Husayn, Ala Ghani. Basal cell markers : 34BE12 and p63, improving detection of basal cells in atypical prostatic lesions. al-Kindy College Medical Journal. 2017. Vol. 13, no. 2, pp.60-63.
https://search.emarefa.net/detail/BIM-796452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 62-63
Record ID
BIM-796452