Evaluation of serum Hepcidin level in Sudanese patients with anemia of chronic renal ailure

Abstract EN

Anemia of chronic renal disease related to the failure of renal excretory functions, and to the renal endocrine function leads to an increased demand for red blood cells.

As a consequence of the shortening of the red blood cells life span, failure of renal endocrine function leads to decreased erythorpoietic response because of impaired production of erythropoietin.

Hepcidin is a major hormonal regulater of iron homeostasis Being synthesized in the liver, it inhibits iron release from macrophages.

It could serve as an indicator of functional iron deficienc, in part, with renal failure Objective: The purpose of this study is to assess the serum hepcidin level in Sudanese patients with anemia of chronic renal failure (ARCF).

Materials and methods: A total of 42 patients diagnosed with anemia of chronic renal failure were enrolled in this study.

Blood serum was extracted from participants, treated and subjected to ELISA test for the estimation of hepcidin level.

A total 42 patients diagnosed with ACRF in Sudan, their ages ranged between (13-79) years (mean SD 4520, the mean value of hepcidin level (13.6) both male 24 (12.7%) and female 18 (14.6%) from different age groups, The hepcidin level correlated with the duration of disease and with gender (p.value<0.05) the relation of hepicdin level and age the p.value showed that more than 0.05 insignificant, no association with age.

Conclusion: It was concluded that it has significant correlation of serum hepcidin level with gender and duration of disease, but no association with RBcs parameters and age.