Synthesis, characterization, biological activity studies of Schiff bases and 1, 3-oxazipene derived from 1, 1-bis (4-aminophenyl)‎-4-phenyl cyclohexane

Abstract EN

A series of new Schiff bases and 1, 3-Oxazepine derivatives have been synthesised from condensation compound (1,1 -bis (4-aminophenyl) -4-phenyl cyclohexane [C1] with different aromatic aldehydes in the presence of catalytic glacial acetic acid to produce the Schiff bases [2-4].

These Schiff bases were reacted with maleic anhydride and phthalic anhydride in dry benzene to give seven-membered heterocyclic ring derivatives [5-10].

The structure formula of these compounds were confirmed by using FT-IR, (1H and 13C) NMR spectroscopy.

The synthesized compounds were screened for their anti‐bacterial activity using ampicillin as a standard drug.