Evaluation of CD14 expression in helicobacter pylori positive and helicobacter pylori negative gastritis

Abstract EN

Monocytes are considered a key mediator of inflammatory cytokine secretions during inflammation.

This study evaluates CD 14 expression in gastritis tissue biopsies of H.

pylori and none H.

pylori gastritis.

This cross-sectional study involved 60 gastritis patients that have been classified into H.

pylori positive (n=30) and H.

pylori negative (n=30).

Formalin fixed paraffin embedded tissue blocks were sectioned and immune-peroxidase staining with anti-CD14, then compared between study groups and clinical parameters.

The results showed a marked difference in the percentage of expression in mild and severe intensity of inflammation sub-groups, the results showed a higher percentage of CD14 immunoreactivity (18.29±5.84 vs.

10.2±3.89, p=0.005) and (42.84±19.43 vs.

32.98±9.83, p=0.007) respectively.

In conclusion, the percentage of CD14 immunoreactivity may closely related to the inflammatory gastritis induced by H.

pylori bacterium.