Histopathological effects of hypericum triquetrifolium on liver and kidney in local rabbits

Abstract EN

This study was undertaken to evaluate the histopathological effects of Hypericum triquetrifolium on the liver and kidneys in local rabbits.

Fourty local rabbits were divided into four equal groups, each of ten animals, two controls (C1 and C2) and two treated groups (T1 and T2).

The control groups (C1 and C2) received no treatment, the group C1 kept in shadow, while group C2 was exposed to direct sunlight 30 minutes daily for 30 days.

The treated groups (T1 and T2) were orally given H.

triquetrifolium with the mixture of diet at a dose of 3 gm/Kg of body weight daily for 30 days.

T1 group was kept in shadow while T2 group was exposed to direct sunlight.

The resuts showed histopathological changes in liver and kidney of the treated group exposed to direct sunlight.

Liver lesions included infiltration of inflammatory cells mainly mononuclear cells in the sinusoids, central vein and portal artery, associated with coagulative necrosis and fatty changes of the hepatocytes.

Kidney lesions included degenerative changes of the renal tubules, cloudy swelling, desquamation of epithelial cells lining the tubules with infiltration of inflammatory cells mainly lymphocytes as well as interstitial edema.

From this study, it was concluded that H.

triquetrifolium at the dose administrated, produced lesions only in the treated group exposed to direct sunlight.