Determination of the level of some adipokines in hypo-and hyperthyroids patients in Baghdad City

Abstract EN

Determination of the level of adipokines (obestatin, vaspin, tumor necrosis factor- and interleukin-6)in hypo-and hyperthyroid patients from Educational Baghdad Hospital in Baghdad City was investigated.

Fifty patients with hypothyroidism and Fifty patients with hyperthyroidism were selected.

A control group of thirty euthyroid persons was included.

Blood was collected by vein puncture and serum was separated and stored at –20C.

Adipokines (obestatin, vaspin, tumor necrosis factor- and interleukin-6) were estimated using ELISA method.

The findings show a significant (p<0.05) increase in obestatin level in hypothyroid patients, while there is no significant difference in hyperthyroid patientsas compared with the euthyroid subjects.

In addition, this study demonstrated a significant (p<0.05) increase in vaspin means in hypothyroid patients compared with euthyroid group.

In hyperthyroid patients, there is a significant (p<0.05) decrease in vaspin level in comparison with euthyroid subjects.

Furthermore, there is a significant (p<0.05) increase in tumor necrosis factor- level in hypothyroid and hyperthyroid patients as compared with the euthyroid subjects.

The results of this study also explain a significant (p<0.05) increase in interleukin-6 level in hyperthyroid patients, while there is non-significant difference in hypothyroid patients compared with the euthyroid subjects.

It is concluded from this study that the levels of interleukin-6 and tumor necrosis factor-  increased in hyperthyroidism and decreased in hypothyroidism.

Obestatin and vaspin were increased significantly in hypothyroid patients.