Impact of two doses of vitamin K2 (Menaquinone-7) on doxorubicin-induced hepatotoxicity in rats
Other Title(s)
تأثير جرعتين من Menaquinone-7 على سمية الكبد المستحثة بواسطة الدوكسوروبيسين في الجرذان
Joint Authors
al-Zubaydi, Ruaa Fadil
al-Shawi, Nada Naji
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 26, Issue 2 (31 Dec. 2017), pp.22-28, 7 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
The objective of this study was to evaluate the impact two doses of Menaquinones-7 on hepatotoxicity induced by doxorubicin in rats.
Sixty adult rats of both sexes were used in this study; the animals were randomly enrolled into six groups of 10 animals each.
Group I: negative control (rats administered distilled water); Group II: Menaquinones-7 at a dose of 16 µg/kg; Group III: Menaquinones-7 at a dose of 48 µg/kg; Group IV: positive control (Doxorubicin 15 mg/kg); Group V: Menaquinones-7 at a dose of 16 µg/kg administered prior to a single dose of Doxorubicin 15 mg/kg; Group VI: Menaquinones-7 at a dose of 48 µg/kg administered prior to a single dose of Doxorubicin 15 mg/kg.
On day twelve of the study, blood was collected for serum preparation for the estimation of alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total bilirubin (TB).
The liver of each animal was excised for histological examination.
High dose of MK-7 significantly (P<0.05) decreased serum ALT, ALP, and TB and there was an improvement in the histopathological lesions of the liver in group V and group VI compared to group IV.
In conclusion, MK-7 may have protective effect against Dox-induced hepatotoxicity in rats.
American Psychological Association (APA)
al-Zubaydi, Ruaa Fadil& al-Shawi, Nada Naji. 2017. Impact of two doses of vitamin K2 (Menaquinone-7) on doxorubicin-induced hepatotoxicity in rats. Iraqi Journal of Pharmaceutical Sciences،Vol. 26, no. 2, pp.22-28.
https://search.emarefa.net/detail/BIM-796926
Modern Language Association (MLA)
al-Zubaydi, Ruaa Fadil& al-Shawi, Nada Naji. Impact of two doses of vitamin K2 (Menaquinone-7) on doxorubicin-induced hepatotoxicity in rats. Iraqi Journal of Pharmaceutical Sciences Vol. 26, no. 2 (Dec. 2017), pp.22-28.
https://search.emarefa.net/detail/BIM-796926
American Medical Association (AMA)
al-Zubaydi, Ruaa Fadil& al-Shawi, Nada Naji. Impact of two doses of vitamin K2 (Menaquinone-7) on doxorubicin-induced hepatotoxicity in rats. Iraqi Journal of Pharmaceutical Sciences. 2017. Vol. 26, no. 2, pp.22-28.
https://search.emarefa.net/detail/BIM-796926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 26-28
Record ID
BIM-796926