Synthesis and characterization of some new Oxazepine compounds derived from Derythroascorbic acid
Other Title(s)
تحضير و تشخيص بعض مركبات الأوكسازبين الجديدة المشتقة من D-حامض الأرثرواسكوربيك
Joint Authors
Fadil, Husayn Ali
Samir, Ali Hammadi
Rumayz, Rasmiyah Mahmud
Source
Iraqi National Journal of Chemistry
Issue
Vol. 16, Issue 4 (31 Dec. 2016), pp.254-267, 14 p.
Publisher
University of Babylon College of Sciences
Publication Date
2016-12-31
Country of Publication
Iraq
No. of Pages
14
Main Subjects
Abstract EN
This search include the synthesis of some new 1,3-oxazepine derivatives have been prepared, starting from reaction of L-ascorbic acid with dry acetone in presence of dry hydrogen chloride afforded the acetal (I).
Treatment of the latter with p-nitrobenzoyl chloride in pyridine yielded the ester (II) which was dissolved in (65%) acetic acid in absolute ethanol yielded the glycol (III).
The reaction of the glycol (III) with sodium periodate in distilled water at room temperature produced the aldehyde (IV).
The compound (V) [4-(1,3-dioxoisoindolin-2-yl)benzoic acid] was synthesized by reaction p-aminobenzoic acid and phthalic anhydride in presence of (gla.
CH3COOH).
Reaction of compound (V) with thionyl chloride produced [4-(1,3-dioxoisoindolin-2-yl)benzoyl chloride].
Condensation of acid chloride with hydrazine hydrate afforded 4-(1,3-dioxoisoindolin-2-yl)benzohydrazide (VI).
The azomethine (VII) has been synthesized from the reaction between compounds (IV) and (VI).
Moreover compounds (VIII-X) were synthesized from the cyclic condensation of Schiff base (VII) with (maleic, phthalic and 3-nitrophthalic) anhydride, the structures of the newly synthesized compounds have been confirmed by physical properties and spectral measurements such as (FTIR and some of them by 1H-NMR and 13C-NMR).
American Psychological Association (APA)
Fadil, Husayn Ali& Samir, Ali Hammadi& Rumayz, Rasmiyah Mahmud. 2016. Synthesis and characterization of some new Oxazepine compounds derived from Derythroascorbic acid. Iraqi National Journal of Chemistry،Vol. 16, no. 4, pp.254-267.
https://search.emarefa.net/detail/BIM-797008
Modern Language Association (MLA)
Fadil, Husayn Ali…[et al.]. Synthesis and characterization of some new Oxazepine compounds derived from Derythroascorbic acid. Iraqi National Journal of Chemistry Vol. 16, no. 4 (2016), pp.254-267.
https://search.emarefa.net/detail/BIM-797008
American Medical Association (AMA)
Fadil, Husayn Ali& Samir, Ali Hammadi& Rumayz, Rasmiyah Mahmud. Synthesis and characterization of some new Oxazepine compounds derived from Derythroascorbic acid. Iraqi National Journal of Chemistry. 2016. Vol. 16, no. 4, pp.254-267.
https://search.emarefa.net/detail/BIM-797008
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 266-267
Record ID
BIM-797008