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The metabolic syndrome and inflammation : role of insulin resistance and increased adiposity
Joint Authors
Faruq, Wajih
Farwa, Umme
Khan, Faysal Rashid
Source
Issue
Vol. 30, Issue 2 (30 Apr. 2015), pp.100-103, 4 p.
Publisher
Publication Date
2015-04-30
Country of Publication
Oman
No. of Pages
4
Main Subjects
Abstract EN
Objectives: We sought to determine the role of obesity and insulin resistance (IR) in the pathogenesis of inflammation in metabolic syndrome (MetS).
Methods: Our study included 100 patients with MetS and 100 age and gender matched control patients who attended a tertiary care laboratory in Rawalpindi, Pakistan.
Anthropometric data was obtained including height and weight to calculate body mass index.
A record of patient’s blood pressure (BP), waist circumference (WC) and hip circumference (HC) was made.
Biochemical analysis included measurements of fasting glucose, triglycerides (TG), highdensity lipoprotein cholesterol (HDL-c), insulin, and high-sensitivity C reactive protein (hsCRP).
IR was determined by the homeostasis mode assessment insulin resistance (HOMA-IR) method.
Results: The levels of hs-CRP were found to be elevated in all patients with MetS where it correlated significantly with all its components including measures of obesity, fasting insulin and glucose levels, IR, TG and HDL-c.
However, on linear regression analysis only WC, fasting insulin, and HOMA-IR remained significantly correlated with hs-CRP.
Conclusion: MetS is a condition characterized by chronic low-grade inflammation, which arises because of increased abdominal adiposity and IR.
Large multicenter studies are needed to gain insight into its pathogenesis and derive treatment strategies
American Psychological Association (APA)
Faruq, Wajih& Farwa, Umme& Khan, Faysal Rashid. 2015. The metabolic syndrome and inflammation : role of insulin resistance and increased adiposity. Oman Medical Journal،Vol. 30, no. 2, pp.100-103.
https://search.emarefa.net/detail/BIM-798332
Modern Language Association (MLA)
Faruq, Wajih…[et al.]. The metabolic syndrome and inflammation : role of insulin resistance and increased adiposity. Oman Medical Journal Vol. 30, no. 2 (2015), pp.100-103.
https://search.emarefa.net/detail/BIM-798332
American Medical Association (AMA)
Faruq, Wajih& Farwa, Umme& Khan, Faysal Rashid. The metabolic syndrome and inflammation : role of insulin resistance and increased adiposity. Oman Medical Journal. 2015. Vol. 30, no. 2, pp.100-103.
https://search.emarefa.net/detail/BIM-798332
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 103
Record ID
BIM-798332