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Comparing intravenous phenylephrine and ephedrine for hypotension during spinal anesthesia for elective cesarean section : a randomized double-blind clinical trial
Joint Authors
Vakili, Hedayatollah
Inayati, Hasan
Dashipour, Ali Rida
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 19, Issue 10 (31 Oct. 2017), pp.1-9, 9 p.
Publisher
Publication Date
2017-10-31
Country of Publication
United Arab Emirates
No. of Pages
9
Main Subjects
Abstract EN
Background: Neuraxial anesthesia is an acceptable technique in pregnant females for cesarean section and up to 71% of pregnant patients have hemodynamic complications, especially hypotension.
Objectives: This study aimed at comparing the effectiveness of phenylephrine versus ephedrine in treatment of maternal hypotension due to spinal anesthesia for elective cesarean section to determine drug efficacy and fewer side effects.
Methods: In this randomized double blind clinical study, 124 pregnant females, who were admitted to Ali ibn Abi Talib hospital in Zahedan, Iran, between 2015and2016, for elective cesarean section, were selected by the Block randomization sampling method.
The samples were divided to 4 groups: Group I received 5mgephedrine bolus, Group II was administered 10mgbolus ephedrine, Group III were delivered phenylephrine bolus of 50 mcg, and Group IV 100 mcg phenylephrine bolus in case of hypotension.
Neonatal outcome and maternal side effects, hemodynamics changes, and Apgar score were controlled and recorded.
Results: In terms of hemodynamic parameters (systolic blood pressure, diastolic blood pressure, and pulse rate), there was a significant difference between the groups (P < 0.0001).
The umbilical arterial pH value and base excess between ephedrine and phenylephrine groups were significantly different (P < 0.0001), and fetal acidosis in the ephedrine group was found.
Nausea and vomiting was significant between the 2 groups (P = 0.03), while the incidence of nausea and vomiting in the ephedrine group was higher than the other groups.
There was no difference between the 2 groups in the first- and fifth-minute Apgar (P = 1).
Conclusions: Control of blood pressure during spinal 50-mcg phenylephrine is recommended.
American Psychological Association (APA)
Vakili, Hedayatollah& Inayati, Hasan& Dashipour, Ali Rida. 2017. Comparing intravenous phenylephrine and ephedrine for hypotension during spinal anesthesia for elective cesarean section : a randomized double-blind clinical trial. Iranian Red Crescent Medical Journal،Vol. 19, no. 10, pp.1-9.
https://search.emarefa.net/detail/BIM-805372
Modern Language Association (MLA)
Vakili, Hedayatollah…[et al.]. Comparing intravenous phenylephrine and ephedrine for hypotension during spinal anesthesia for elective cesarean section : a randomized double-blind clinical trial. Iranian Red Crescent Medical Journal Vol. 19, no. 10 (Oct. 2017), pp.1-9.
https://search.emarefa.net/detail/BIM-805372
American Medical Association (AMA)
Vakili, Hedayatollah& Inayati, Hasan& Dashipour, Ali Rida. Comparing intravenous phenylephrine and ephedrine for hypotension during spinal anesthesia for elective cesarean section : a randomized double-blind clinical trial. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 10, pp.1-9.
https://search.emarefa.net/detail/BIM-805372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 8-9
Record ID
BIM-805372