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TP53 codon 72 genetic polymorphism, rs1042522, modifies the association between tobacco smoking and breast cancer risk
Joint Authors
Nabipour, Iraj
Ostovar, Afshin
Moradinasab, Maryam
Eghbali, Sayyid Sajjad
Vahdat, Katayoun
Ghaderi, Abbas
Farzaneh, Muhammad Rida
Ravanbod, Muhammad Rida
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 19, Issue 10 (31 Oct. 2017), pp.1-6, 6 p.
Publisher
Publication Date
2017-10-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Abstract EN
Background: TP53 tumor suppressor gene participates in several pathways involving in carcinogenesis such as cell cycle control, DNA repair, and apoptosis.
A common TP53 SNP (guanine/cytosine nucleotide substitution at codon 72), rs1042522, affects the function of p53 protein and may influence tumor behavior in response to environmental carcinogens.
Objectives: This study investigates the association between TP53 codon 72 polymorphisms, tobacco smoking, and breast cancer risk in southern Iranian women from Bushehr.
Methods: A case-control study was conducted on 144 cases with histologically confirmed invasive breast carcinoma and 162 randomly selected healthy controls with no previous cancer history in their family.
TP53 codon 72 genotype was determined by using restriction fragment length polymorphism- polymerase chain reaction (RFLP-PCR) technique.
Results: Analysis revealed that smoking frequency was significantly higher in cases compared to controls (OR = 2.31, 95%CI = 1.33-3.99, P = 0.003) and the association between smoking and breast cancer was only significant for individuals with Arg/Pro genotype (OR = 3.23, 95% CI = 1.47 - 7.06, P = 0.003).
On the other hand, there was no statistically considerable difference in the allele and genotype distribution between cases and controls.
Conclusions: These results should be confirmed in larger studies, but suggest that TP53 Arg/Pro genotype modifies the risk of breast cancer in tobacco smokers and causes significantly more susceptibility to breast cancer due to smoking.
American Psychological Association (APA)
Moradinasab, Maryam& Ostovar, Afshin& Nabipour, Iraj& Eghbali, Sayyid Sajjad& Vahdat, Katayoun& Ghaderi, Abbas…[et al.]. 2017. TP53 codon 72 genetic polymorphism, rs1042522, modifies the association between tobacco smoking and breast cancer risk. Iranian Red Crescent Medical Journal،Vol. 19, no. 10, pp.1-6.
https://search.emarefa.net/detail/BIM-805504
Modern Language Association (MLA)
Moradinasab, Maryam…[et al.]. TP53 codon 72 genetic polymorphism, rs1042522, modifies the association between tobacco smoking and breast cancer risk. Iranian Red Crescent Medical Journal Vol. 19, no. 10 (Oct. 2017), pp.1-6.
https://search.emarefa.net/detail/BIM-805504
American Medical Association (AMA)
Moradinasab, Maryam& Ostovar, Afshin& Nabipour, Iraj& Eghbali, Sayyid Sajjad& Vahdat, Katayoun& Ghaderi, Abbas…[et al.]. TP53 codon 72 genetic polymorphism, rs1042522, modifies the association between tobacco smoking and breast cancer risk. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 10, pp.1-6.
https://search.emarefa.net/detail/BIM-805504
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-805504