Assessment of vitamin D binding protein in Egyptian cystic filbrosis children and its relation to serum Immunoglobulin G.

Abstract EN

Background: Vitamin D binding protein DBP is a multifunctional transport protein.

The aim of the present study is to measure the level of DBP and serum 25-hvdroxyvitamin D 250HD in order to assess its role as a nutntional marker in CF.

In the context of the recently described immunomodulatory functions of vitamin D, the relationship between vitamin DBP and immunoglobulin G IgG levels was assessed.

Methods: This is a cross sectional case controlled observational study recruiting 50 patients diagnosed as CF (cystic fibrosis).

They were referred to Allergy and Pulmonology Unit, Aboreesh Children’s Hospital, Cairo University.

Their age ranged from 18 months to 13 years.

DBP and 250HD were measured using Elisa technique and IgG was measured using nephelometer method.

Results: CF group had significant lower serum concentrations of DBP p<0.012 and 250HD p<0.001 while IgG levels were within normal values p<0.216 compared to the control group.

Significant positive correlations were observed between IgG and age r=0.528, p<0.01 weight r=0.480, p<0.001 and height r=0.509, p<0.001.

Significant positive relations were observed between failure to thrive and DBP p=0.023 and 250HD p=0.003.

A significant positive relation between DBP and pancreatic insufficiency p=0.039.No significant correlations were observed between DBP and 250HD r=-0.224, p=0.118, between DBP and IgG r=0.195.

p =0.176.

Between DBP and sweat chloride test r=0.201, p=0.162, between 250HD and IgG r=0.195, p=0.176.No significant relations were observed between pancreatic insufficiency, and 250HD p=0.944 and IgG p=0.332, between failure to thrive and IgG p=0.898 Conclusions: DBP and 250HD levels were decreased in CF patients; and IgG levels were within normal values and positively correlated with age, weight and height significant relations of DBP with failure to thrive and pancreatic insufficiency emphasizing its role as a marker for the nutritional status in CF patients.