Evaluation of diagnostic markers of early onset neonatal sepsis
Other Title(s)
تقييم علامات التشخيص المبكر للتسمم الدموي لحديثي الولادة
Joint Authors
al-Jamal, Hanan Abd Allah
Bakr, Salwa Ibrahim
Abu Gharib, Manal Ismat
Source
Issue
Vol. 19, Issue 70 (31 Jan. 2016), pp.1-6, 6 p.
Publisher
Ain Shams University Faculty of Graduate Studies for Childhood
Publication Date
2016-01-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background: Early diagnosis of neonatal sepsis decreases morbidity and mortality in neonates.
Recently, serum procalcitonin (PCT) has been investigated as a new marker for the detection of bacterial infection.
Objectives: to evaluate procalcitonin (PCT) as an early marker of neonatal infections, and to compare procalcitonin with interleukin- 6 (IL- 6), C- reactive protein (CRP), hematological scoring systems (HSS).
Methods: This cross sectional study included 90 neonates divided into three groups: 30 neonates as proved septic group, 30 neonates as suspected septic group and 30 healthy control neonates.
All studied neonates were investigated at age of 1-2 days of life for serum PCT, IL- 6, CRP, hematological score by using HSS.
Results: Serum PCT, IL- 6, CRP were significantly elevated in septic groups in comparison to the control group.
The area under the ROC curve for PCT was 0.97, with specificity of 96.7%, sensitivity of 93.3%.
Negative predictive value of 93.5% positive predictive value of 96.6%, diagnostic efficacy of 95%, which is significantly higher than that of IL- 6 and CRP.
No correlation was found between PCT, IL- 6, CRP.
HSS was not an early tool for diagnosing of neonatal sepsis.
Conclusion: PCT is superior to IL- 6 and CRP in diagnosis of early onset neonatal sepsis
American Psychological Association (APA)
al-Jamal, Hanan Abd Allah& Bakr, Salwa Ibrahim& Abu Gharib, Manal Ismat. 2016. Evaluation of diagnostic markers of early onset neonatal sepsis. Journal of Childhood Studies،Vol. 19, no. 70, pp.1-6.
https://search.emarefa.net/detail/BIM-809442
Modern Language Association (MLA)
al-Jamal, Hanan Abd Allah…[et al.]. Evaluation of diagnostic markers of early onset neonatal sepsis. Journal of Childhood Studies Vol. 19, no. 70 (Jan. 2016), pp.1-6.
https://search.emarefa.net/detail/BIM-809442
American Medical Association (AMA)
al-Jamal, Hanan Abd Allah& Bakr, Salwa Ibrahim& Abu Gharib, Manal Ismat. Evaluation of diagnostic markers of early onset neonatal sepsis. Journal of Childhood Studies. 2016. Vol. 19, no. 70, pp.1-6.
https://search.emarefa.net/detail/BIM-809442
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-809442