Identification of 27bp variable tandem repeats in endothelial nitric oxide synthase (eNOS) gene of hypertensive subjects in Kurdish population from Erbil city
Joint Authors
Mustafa, Suhad A.
Abd al-Wahid, Muhsin J.
Source
Iraqi Journal of Biotechnology
Issue
Vol. 16, Issue 4 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
University of Baghdad Genetic Engineering and Biotechnology for Postgraduate Studies
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
Hypertension is a multifactorial and polygenic disorder where several susceptible genes interact with the environmental factors.
Endothelial nitric oxide synthase (eNOS) produces nitric oxide (NO) which is involved in many physiologic regulatory functions.
Variable number of tandem repeats in intron 4 of endothelial nitricoxide synthase gene are reported to be associated with blood pressure regulation.
In the present study, we examined possible association between the 27 base pair (bp) repeat polymorphism in intron 4 of the eNOS3 gene and hypertension in a Kurdish population from Erbil city.
Fifty eight patients with hypertension and 42 apparently healthy controls were included in the study.
Genotyping was performed by polymerase chain reaction (PCR).
The genotype frequencies for eNOS4b/b, eNOS4a/b and eNOS4a/a were 55%, 23.8% and 21.2% in control group, and 70.7%, 24.2% and 5.1% in hypertensive group, respectively.
The eNOS bb genotype (70.7%vs 55%) was found to be significantly associated with hypertension (P=0.000, OR= 7.14: 95% CI; 3.025-16.85) which indicated that the odds of hypertensive is about seven times higher in bb genotype compared to control (OR= 2.38,95% CI;1.55-3.64), whereas eNOS aa were significantly more frequent in controls (21.2 % vs.
5.1 P=0.014) which indicated that this genotype associated with decrease in the risk of having hypertension.
(P=0.014)
American Psychological Association (APA)
Mustafa, Suhad A.& Abd al-Wahid, Muhsin J.. 2017. Identification of 27bp variable tandem repeats in endothelial nitric oxide synthase (eNOS) gene of hypertensive subjects in Kurdish population from Erbil city. Iraqi Journal of Biotechnology،Vol. 16, no. 4, pp.1-7.
https://search.emarefa.net/detail/BIM-810982
Modern Language Association (MLA)
Mustafa, Suhad A.& Abd al-Wahid, Muhsin J.. Identification of 27bp variable tandem repeats in endothelial nitric oxide synthase (eNOS) gene of hypertensive subjects in Kurdish population from Erbil city. Iraqi Journal of Biotechnology Vol. 16, no. 4 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-810982
American Medical Association (AMA)
Mustafa, Suhad A.& Abd al-Wahid, Muhsin J.. Identification of 27bp variable tandem repeats in endothelial nitric oxide synthase (eNOS) gene of hypertensive subjects in Kurdish population from Erbil city. Iraqi Journal of Biotechnology. 2017. Vol. 16, no. 4, pp.1-7.
https://search.emarefa.net/detail/BIM-810982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-7
Record ID
BIM-810982