The role of single nucleotide polymorphism (C T)‎ of TGF-β1 gene at position-509 in the promoter region in progression of breast cancer among some Iraqi women

Abstract EN

Risk of breast cancer incidence among women can influence by many gencs polymorphisms that cause différent variations in their expression.

Transforming growth factor-jîl (TGF-pl ) has clear rôle in progression and invasion of breast carcinoma.

Spécifié polymorphic variants in TGF-fJl gcnc correlatc with incrcascd its expression or loss of inhibition.

This study was aimed to find out if the single nuclcotidc polymoiphism C/T at position -509 in the promoter région of TGF-fil gcnc with its génotypes can bc considcred as predisposing factors of in 58 Iraqi women with confirmed breast cancer who were admitted to Alsadcr Tcaching Hospital in Al-Najaf province.

Polymerasc chain rcaction-restriction fragment lcngth polymorphism technique was used to estimate genotyping of TGF-pl gcnc polymorphism in the patients and 30 hcalthy women without any inflammatory' disorders or clinical manifestation of any disease (control group).

Génotype distributions of SNP (-509 C/T) showed no signifieant différence (p>0.05) between patients (CC: n= 45, 77.58%; CT: n=ll, 18.96%; TT: n=2, 3.44%) and Controls (CC: n= 25, 83.33%; CT: n=5, 16.66%; TT: n=0).

That means the SNP C / T inposition 509 in the promoter région ofTGF-pl gcnc plays no signifieant rôle in the progression of breast cancer among Iraqi fcmalc patients.