A study of cytogenetic effects of Indomethacin and glucosamine drugs in some fertility genes in male Albino rats

Abstract EN

The genotoxicity of Indomethacin and glucose amine was studied in four genes of the fertility genes of male rats (PTGR2, GSTP1, HSP70, IGFBP3) and at 7 mg / kg, 21 mg / kg respectively for two drugs , drinked for 21 days and 4 groups each 4 rats, including the control group, which was drinked with distilled water.

DNA was extracted for the tissue cells of both the testes and epidydamises ,genes was studied by pcr technique and electrophoreses on agarose gel .

A significant effect was observed on the genes isolated from the epididymal cells compared to the testes in all the genes under study except for the HSP70 gene, its not been any effect in both the testes and the epididymises.