Pathological study of subchronic oral toxicity induced by Di (2-ethyl hexyl) phthalate in Japanese quails
Other Title(s)
دراسة مرضية للتسمم الفموي تحت المزمن المحدث بثنائي (2-اثيل هسكيل) فثالات في طيور السمان الياباني
Joint Authors
al-Mahmud, Sivan Sad Fadil
al-Abbadi, Said Majid Said
Source
Iraqi Journal of Veterinary Sciences
Issue
Vol. 31, Issue 2 (31 Dec. 2017), pp.67-71, 5 p.
Publisher
University of Mosul College of Veterinary Medicine
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Abstract EN
In present study, we aimed to investigate the pathological changes induced by subchronic oral toxicity induced by sub lethal dose of Di (2-ethyl hexyl) phthalate (DEHP) in Japanese common quail.
Forty male quails at one day old were divided randomly into two equal groups, the first group (treated group) was orally administrated by 10% of LD50 of DEHP (557.41 mg/kg of body weight) for 42 days, while second group (control group) left without treatment throughout experiment period.
The results of current study showed that there is congestion of kidney, microscopically they showed presence of hyaline degeneration in renal tubules, glomerulosclerosis, wide spread of degenerative and necrotic lesions in renal tubules, hemorrhage, infiltration of inflammatory cell especially macrophages and lymphocytes in interstitial tissue of kidney.
While grossing of liver showed hepatomegaly with hemorrhage, microscopically the sections showed wide distributing of vacuolar degeneration (fatty change) in different size and shape of vacuoles in cytoplasm of affected hepatocytes, infiltration of inflammatory cells mainly macrophages and lymphocytes.
In conclusion, the oral administration of DEHP at dose 557.41 mg/kg of body weight for 42 days induced degenerative and necrotic irreversible changes in both kidney and liver of Japanese quail that affect their health and production.
American Psychological Association (APA)
al-Mahmud, Sivan Sad Fadil& al-Abbadi, Said Majid Said. 2017. Pathological study of subchronic oral toxicity induced by Di (2-ethyl hexyl) phthalate in Japanese quails. Iraqi Journal of Veterinary Sciences،Vol. 31, no. 2, pp.67-71.
https://search.emarefa.net/detail/BIM-812178
Modern Language Association (MLA)
al-Mahmud, Sivan Sad Fadil& al-Abbadi, Said Majid Said. Pathological study of subchronic oral toxicity induced by Di (2-ethyl hexyl) phthalate in Japanese quails. Iraqi Journal of Veterinary Sciences Vol. 31, no. 2 (2017), pp.67-71.
https://search.emarefa.net/detail/BIM-812178
American Medical Association (AMA)
al-Mahmud, Sivan Sad Fadil& al-Abbadi, Said Majid Said. Pathological study of subchronic oral toxicity induced by Di (2-ethyl hexyl) phthalate in Japanese quails. Iraqi Journal of Veterinary Sciences. 2017. Vol. 31, no. 2, pp.67-71.
https://search.emarefa.net/detail/BIM-812178
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 71
Record ID
BIM-812178