Strain differences in cannabinoid-reinforced lever press discrimination

Joint Authors

Ucha, Marcos
Coria, Santiago M.
Higuera Matas, Alejandro
Ambrosio, Emilio
Roura Martınez, David
Orihuel, Javier

Source

Journal of Drug and Alcohol Research

Issue

Vol. 6, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.

Publisher

Ashdin Publishing Corporation

Publication Date

2017-12-31

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Pharmacy, Health & Medical Sciences

Abstract EN

Background.

The Lewis (LEW) and Fischer 344 (F344) rat strains have been typically used to study certain genetic influences on drug use.

There are important differences between these strains in terms of the self-administration of several drugs and in several neurochemical messengers including the endocannabinoid system.

Purpose.

To investigate whether these two strains exhibit differences in the self-administration of the cannabinoid agonist WIN 55,512-2.

Results.

Stable WIN 55,512-2 self-administration behavior was not achieved by either strain, but both exhibited some degree of active/inactive lever discrimination, with LEW rats showing better performance in this index.

Injection of the CB1 receptor antagonist/inverse agonist AM251 decreased active lever pressing in F344 rats.

During extinction, we observed a nonsignificant increase in lever pressing, which subsequently disappeared.

Conclusion.

Our results point to subtle genetic influences in the sensitivity to cannabinoid reward that may contribute to interindividual differences in marihuana use and abuse in humans

American Psychological Association (APA)

Coria, Santiago M.& Roura Martınez, David& Ucha, Marcos& Orihuel, Javier& Higuera Matas, Alejandro& Ambrosio, Emilio. 2017. Strain differences in cannabinoid-reinforced lever press discrimination. Journal of Drug and Alcohol Research،Vol. 6, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-812767

Modern Language Association (MLA)

Coria, Santiago M.…[et al.]. Strain differences in cannabinoid-reinforced lever press discrimination. Journal of Drug and Alcohol Research Vol. 6 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-812767

American Medical Association (AMA)

Coria, Santiago M.& Roura Martınez, David& Ucha, Marcos& Orihuel, Javier& Higuera Matas, Alejandro& Ambrosio, Emilio. Strain differences in cannabinoid-reinforced lever press discrimination. Journal of Drug and Alcohol Research. 2017. Vol. 6, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-812767

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 5-6

Record ID

BIM-812767