Correlation of intraoperative frozen section report and histopathological diagnosis of central nervous system tumors : a six-year retrospective study
Joint Authors
al-Kindi, Hunaynah Muhammad
al-Ajmi, Radiyah
George, Mina
Thomas, Kurien
Source
Issue
Vol. 31, Issue 6 (30 Nov. 2016), pp.414-420, 7 p.
Publisher
Publication Date
2016-11-30
Country of Publication
Oman
No. of Pages
7
Main Subjects
Abstract EN
Objectives: To evaluate the degree of agreement between the intraoperative frozen section (FS) reporting of central nervous system (CNS) tumors and final histopathological diagnosis based on permanent paraffin section.
Methods: All CNS tumor cases with a diagnosis at FS and subsequent permanent section (n = 261) taken from 2007 to 2012 were retrospectively reviewed.
Twenty percent of FS were double-checked by a senior pathologist as part of the study and the intraobserver agreement between the pathologist and the agreement between final report, and initial FS report was estimated by the intraclass correlation coefficient (ICC).
Results: A total of 261 cases were reviewed.
The most common diagnosis was glioblastoma (grade IV) and meningioma (grade I–II) forming 45.6% of cases.
Fifty-three cases were subjected to intraobserver agreement of histological diagnosis.
There was nearly perfect intraobserver agreement on histopathology (ICC = 0.9).
Out of 261 cases, 224 cases showed a strong agreement between the FS diagnosis and final histological diagnosis (ICC = 0.747).
A discrepancy between the FS and final diagnosis were found in eight cases.
The disagreement did not relate to any specific tumor type.
However, in three cases, the discrepancy was in the grading of the glioma.
In 29 cases, a definite opinion could not be given on FS as the samples examined were nonrepresentative.
Conclusions: Histopathological slides classified by World Health Organization criteria of CNS tumors had excellent intraobserver agreement.
Our results show a moderate to high degree of agreement in the intraoperative diagnosis of CNS lesions using FS.
However, there are limitations, and some lesions are a diagnostic challenge.
There is a need to improve our diagnostic skills and knowledge of possible errors and establish better communication with neurosurgeons.
American Psychological Association (APA)
al-Ajmi, Radiyah& al-Kindi, Hunaynah Muhammad& George, Mina& Thomas, Kurien. 2016. Correlation of intraoperative frozen section report and histopathological diagnosis of central nervous system tumors : a six-year retrospective study. Oman Medical Journal،Vol. 31, no. 6, pp.414-420.
https://search.emarefa.net/detail/BIM-813241
Modern Language Association (MLA)
al-Ajmi, Radiyah…[et al.]. Correlation of intraoperative frozen section report and histopathological diagnosis of central nervous system tumors : a six-year retrospective study. Oman Medical Journal Vol. 31, no. 6 (Nov. 2016), pp.414-420.
https://search.emarefa.net/detail/BIM-813241
American Medical Association (AMA)
al-Ajmi, Radiyah& al-Kindi, Hunaynah Muhammad& George, Mina& Thomas, Kurien. Correlation of intraoperative frozen section report and histopathological diagnosis of central nervous system tumors : a six-year retrospective study. Oman Medical Journal. 2016. Vol. 31, no. 6, pp.414-420.
https://search.emarefa.net/detail/BIM-813241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 419-420
Record ID
BIM-813241