Correlation between metformin and vitamin B12 level among type II diabetics in southern Gaza

Abstract EN

Metformin is the cornerstone in the treatment of diabetes and is the most frequently prescribed as the first line therapy for individuals with type 2 diabetes.

Objective: To determine the correlation between vitamin B12 and metformin in diabetes mellitus type II patients treated by metformin in Southern Gaza.

Methodology and tools This case control descriptive study comprised of 80 diabetic participants divided equally into two groups: experimental group, 40 diabetics patients taking metformin, and control group, 40 diabetics not taking metformin, aged between 50-95years old.

Interviews were conducted.

Serum vitamin B12 and CBC were measured.

Data were analyzed using SPSS version 20.

Results: VitaminB12 deficiency was present in 30% of the cases and non apparent in the control group had deficient vitaminB12.

There were statistically significant negative association between dose and vitamine B12.

Besides, there was statistically significant negative association between duration and vitamine B12, by means of an increase in duration will lead to decrease in vitamin B12 level.

Blood rofile analysis showed a statistically significant positive association between vitamin B12 and Hb, WBC , RBC and PLT; vitamin B12 decrease will lead to a decrease in Hb, WBC, RBC and PLT at (be less than 0.05).

Conclusion: Vitamin B12 deficiency occurs more frequently in patients with type 2 diabetes with longer duration of metformin use and in those taking larger amounts of metformin.

There was a clear side effect of metformin use on most of blood indices.