Toxic effect of nerium oleander leaves extract on biochemical parameters in rabbits serum
Other Title(s)
التأثير السام لمستخلص أوراق نبات الدفلة على التغييرات الكيمياوية الحيوية في مصل الأرانب
Joint Authors
al-Khayyat, Ali Aziz Abd
Salih, Rana Abd Allah
Source
al-Anbar Journal of Veterinary Sciences
Issue
Vol. 9, Issue 2 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Publication Date
2016-12-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
The study involved collection of the Nerium oleander leaves of two seasons (summer and winter) in 2014 which was taken from Baghdad (Amiriya).
The leaves prepared by drying, grinding, the extraction which was carried by soxhlet apparatus with organic solvent (hexane).
The pilot study (by using two rabbits for each dose of N.
oleander extracts of the two seasons) was done for determining the range of doses which used.
The median lethal dose (LD50) which was carried out by "up and down" method was (94.36) mg/kg B.Wt.
for summer extract and (79.75) mg/kg B.Wt.
for winter extract of N.
oleander leaves.
The chronic toxicity were carried out on rabbits by giving 10% of the dose that obtained by acute toxicity study and by considering different serum parameters after two weeks and four weeks of daily treatment.
These parameters include serum potassium, calcium levels, serum ALT, AST and ALP levels.
Biochemical study shown serum liver enzymes (ALT, AST, and ALP) was elevated in both groups (summer and winter) as compare to digoxin and control groups in different times (two weeks and four weeks), also increase serum K+ level as hyperkalemia and decrease serum Ca++ level as hypocalcaemia.
We concluded that the N.
oleander leaves extract has toxic effect on liver enzymes (ALT, AST and ALP), also effect on serum calcium and potassium levels, also the winter extract more effect than that in summer extract.
American Psychological Association (APA)
Salih, Rana Abd Allah& al-Khayyat, Ali Aziz Abd. 2016. Toxic effect of nerium oleander leaves extract on biochemical parameters in rabbits serum. al-Anbar Journal of Veterinary Sciences،Vol. 9, no. 2, pp.1-8.
https://search.emarefa.net/detail/BIM-815810
Modern Language Association (MLA)
Salih, Rana Abd Allah& al-Khayyat, Ali Aziz Abd. Toxic effect of nerium oleander leaves extract on biochemical parameters in rabbits serum. al-Anbar Journal of Veterinary Sciences Vol. 9, no. 2 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-815810
American Medical Association (AMA)
Salih, Rana Abd Allah& al-Khayyat, Ali Aziz Abd. Toxic effect of nerium oleander leaves extract on biochemical parameters in rabbits serum. al-Anbar Journal of Veterinary Sciences. 2016. Vol. 9, no. 2, pp.1-8.
https://search.emarefa.net/detail/BIM-815810
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-815810