Acute toxicity study of alcoholic leaf extract of eruca sativa in albino rats (Rattus norvegicus)
Other Title(s)
دراسة السمية الحادة للمستخلص الكحولي لنبات الجرجير في الجرذان البيض
Joint Authors
Salih, Marwan Mahmud
Qadir, Suhaylah Wasman
Dhakir, Abd Ali
Source
al-Anbar Journal of Veterinary Sciences
Issue
Vol. 8, Issue 2 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Abstract EN
Eruca sativa (Es) belongs to the family Brassicaceae (Cruciferae) commonly known as jarjeer have been used in traditional medicine for treatment of different diseases.
The present study was performed to evaluate the acute toxicity of Eruca sativa ethanolic leaves extract (ESELE) in rats.
For acute toxicity test, fifteen rats have been used and they were divided into three groups with five rats for each group, low dose of ESELE (2g/kg), high dose of ESELE (5 g/kg) and normal group.
After 14 days all the animals were sacrificed by intraperitonial injection with ketamine (100 mg/ml) and xylazine (100mg/ml) in a ratio 4:1 (v/v).
The blood was collected for some liver function test such as [aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total serum bilirubin (TSB)] and kidney function test such as (urea and creatinine).
Then liver and kidney were fixed in formalin 10% for histopathological examination.
Acute toxicity study with a higher dose of 5 g/kg did not manifest any toxicological signs in rats.
There is no significant (P≤0.05) difference between rats was given ESELE in all tested parameters levels as compared to their respective vehicle group.
Histopathological examination of the organs did not reveal any abnormalities in all groups treated comparing with vehicle group.
In conclusions, the present finding suggests that ESELE did not manifest any significant toxicity at any of the biochemical and histological examined parameters
American Psychological Association (APA)
Salih, Marwan Mahmud& Qadir, Suhaylah Wasman& Dhakir, Abd Ali. 2015. Acute toxicity study of alcoholic leaf extract of eruca sativa in albino rats (Rattus norvegicus). al-Anbar Journal of Veterinary Sciences،Vol. 8, no. 2, pp.1-9.
https://search.emarefa.net/detail/BIM-816335
Modern Language Association (MLA)
Salih, Marwan Mahmud…[et al.]. Acute toxicity study of alcoholic leaf extract of eruca sativa in albino rats (Rattus norvegicus). al-Anbar Journal of Veterinary Sciences Vol. 8, no. 2 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-816335
American Medical Association (AMA)
Salih, Marwan Mahmud& Qadir, Suhaylah Wasman& Dhakir, Abd Ali. Acute toxicity study of alcoholic leaf extract of eruca sativa in albino rats (Rattus norvegicus). al-Anbar Journal of Veterinary Sciences. 2015. Vol. 8, no. 2, pp.1-9.
https://search.emarefa.net/detail/BIM-816335
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-816335