Forensic pathology and newborn screening for inborn errors of metabolism : implications for the Middle East
Other Title(s)
العالقة بني علم الأمراض الجنائي و فحص الأخطاء الوراثية للأيض (الاستقلاب) عند حديثي الوالدة : الانعكاسات على الشرق الأوسط
Joint Authors
Sulayman, Yazan Ali
Rasul, Mustafa
al-Ali, Zayd
Hamid, Abd Ali
Jamil, Amir
Martinez, Soledad
Pollanen, Michael S.
Source
Arab Journal of Forensic Sciences and Forensic Medicine
Issue
Vol. 1, Issue 4 (31 Dec. 2016), pp.438-442, 5 p.
Publisher
Naif Arab University for Security Sciences Arab Society for Forensic Sciences and Forensic Medicine
Publication Date
2016-12-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
We report the postmortem findings of two infants and one child who died in Iraq.
In each case, a specific clinical diagnosis was never established and all died at home.
None of the cases had undergone newborn screening tests for inherited diseases.
In case 1, a 3-day old neonate died without ever passing meconium.
Autopsy revealed complete small intestinal obstruction due to meconium ileus.
This was most likely due to cystic fibrosis.
In case 2, a 6 month old boy died suddenly and unexpectedly after developing dehydration from vomiting.
Autopsy revealed marked hepatomegaly with fatty infiltration that also involved the myocardium and kidney.
This was most likely due to Medium Chain Aacyl Co-A dehydrogenase (MCAD) deficiency.
In case 3, a 12-year-old boy died after a progressive neurological disorder of childhood.
At autopsy, the body showed cachexia and flexion contractions.
The brain showed loss of white matter bulk and thinning of the corpus callosum.
The major organs showed no abnormalities.
Histologic examination revealed only mild spongy change of the white matter.
These findings indicate that the child likely had an organic acidemia, most probably phenylketonuria (PKU).
These cases highlight the critical importance of newborn screening for inborn errors of metabolism in Iraq, including laboratory testing for PKU, MCAD deficiency and cystic fibrosis.
Such screening can prevent unnecessary morbidity and mortality in infants and children.
On this basis, forensic pathologists should advocate for widespread newborn screening in the Middle East.
American Psychological Association (APA)
Sulayman, Yazan Ali& Rasul, Mustafa& al-Ali, Zayd& Hamid, Abd Ali& Jamil, Amir& Martinez, Soledad…[et al.]. 2016. Forensic pathology and newborn screening for inborn errors of metabolism : implications for the Middle East. Arab Journal of Forensic Sciences and Forensic Medicine،Vol. 1, no. 4, pp.438-442.
https://search.emarefa.net/detail/BIM-818843
Modern Language Association (MLA)
Sulayman, Yazan Ali…[et al.]. Forensic pathology and newborn screening for inborn errors of metabolism : implications for the Middle East. Arab Journal of Forensic Sciences and Forensic Medicine Vol. 1, no. 4 (Dec. 2016), pp.438-442.
https://search.emarefa.net/detail/BIM-818843
American Medical Association (AMA)
Sulayman, Yazan Ali& Rasul, Mustafa& al-Ali, Zayd& Hamid, Abd Ali& Jamil, Amir& Martinez, Soledad…[et al.]. Forensic pathology and newborn screening for inborn errors of metabolism : implications for the Middle East. Arab Journal of Forensic Sciences and Forensic Medicine. 2016. Vol. 1, no. 4, pp.438-442.
https://search.emarefa.net/detail/BIM-818843
Data Type
Journal Articles
Language
English
Record ID
BIM-818843