Immunohistochemical expression of aromatase in malignant breast tumours
Other Title(s)
التعبير النسجي-الكيميائي-المناعي للأرومتيز في أورام الثدي الخبيثة
Joint Authors
Abbas, Hanan Dikan
Shafi, Farha Abd Ali
Abd al-Jabbar, Rawa Abd al-Amir
Source
Iraqi Journal of Cancer and Medical Genetics
Issue
Vol. 9, Issue 2 (31 Dec. 2016), pp.138-143, 6 p.
Publisher
al-Mustansyriah University Iraqi Centre for Cancer and Medical Genetics Research
Publication Date
2016-12-31
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Abstract EN
-Twenty tumour biopsies of Iraqi breast cancer female patients were examined for immunohistochemical (IHC) expression of aromatase.
The expression was correlated with age and histopathological type, grade and clinical staging of tumour.
Results revealed that out of the 20 investigated cases, 75.0% showed positive IHC expression of aromatase, which was distributed as 35.0% for score 2+ and 40.0% for score 3+.
The remaining five negative cases (25.0%) were observed to have the lowest age mean (38.6 ± 4.4 years), which was significantly different from the recorded age mean in patients with the score 2+ (53.6 ± 3.2 years; p = 0.008) or 3+ (49.4 ± 2.8; p = 0.04), but no significant difference was observed between age means of positive cases.
A histpathological examination of tumours revealed that they were invasive ductal carcinoma (IDC) but of two types: tubular IDC (5 cases; 25.0%) and 15 cases (75.0%) were defined as not otherwise specified (IDC-NOS).
In tubular IDC, most of cases (80.0%) had 3+ score, while in IDC-NOS, it was 26.7%.
Such difference was significant (p = 0.023).
Distributing patients by grade and stage of tumours revealed no significant difference in IHC scoring of aromatase or age.
It is possible to conclude that positive IHC expression of aromatase is tended to occur in older ages (around 50 years) of breast cancer patients.
American Psychological Association (APA)
Abd al-Jabbar, Rawa Abd al-Amir& Shafi, Farha Abd Ali& Abbas, Hanan Dikan. 2016. Immunohistochemical expression of aromatase in malignant breast tumours. Iraqi Journal of Cancer and Medical Genetics،Vol. 9, no. 2, pp.138-143.
https://search.emarefa.net/detail/BIM-818964
Modern Language Association (MLA)
Abd al-Jabbar, Rawa Abd al-Amir…[et al.]. Immunohistochemical expression of aromatase in malignant breast tumours. Iraqi Journal of Cancer and Medical Genetics Vol. 9, no. 2 (2016), pp.138-143.
https://search.emarefa.net/detail/BIM-818964
American Medical Association (AMA)
Abd al-Jabbar, Rawa Abd al-Amir& Shafi, Farha Abd Ali& Abbas, Hanan Dikan. Immunohistochemical expression of aromatase in malignant breast tumours. Iraqi Journal of Cancer and Medical Genetics. 2016. Vol. 9, no. 2, pp.138-143.
https://search.emarefa.net/detail/BIM-818964
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-818964