Antiproliferative effects and apoptosis induction of ethanolic extract of Andrachna aspera on Human rabdomyosarcoma cells
Other Title(s)
التأثير التثبيطي و تحفيز موت الخلايا لمستخلص الايثانولي لنبات Andrachna aspera على خط الخلايا السرطانية RD
Author
Source
Iraqi Journal of Cancer and Medical Genetics
Issue
Vol. 8, Issue 1 (30 Jun. 2015), pp.46-51, 6 p.
Publisher
al-Mustansyriah University Iraqi Centre for Cancer and Medical Genetics Research
Publication Date
2015-06-30
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Arial part of Andrachna aspera ethanolic extract was evaluated by studying their effect on human rabdomyosarcoma (RD) cell line.
The cytotoxic activity was determined by anti-proliferative effects when the human rabdomyosarcoma cells were cultured under different concentrations.
After 24, 48 and 72h when treated with the ethanolic extract, using cell viability assay.
The plant extract showed the strong cytotoxic affect upon the cell like RD with IC50 of 25 µg/ml concentration after 72h, Furthermore, cell cycle analysis showed a significant increase in the accumulation of RD- treated cells at G0/G1 phase (p<0.01), and apoptotic rate also shows significantly increasing in a dose- time dependent manner.The extract of A.
aspera induced apoptosis and possessed the most robust anticancer activity, against RD cells
American Psychological Association (APA)
Hidayat, Hazha Jamal. 2015. Antiproliferative effects and apoptosis induction of ethanolic extract of Andrachna aspera on Human rabdomyosarcoma cells. Iraqi Journal of Cancer and Medical Genetics،Vol. 8, no. 1, pp.46-51.
https://search.emarefa.net/detail/BIM-819037
Modern Language Association (MLA)
Hidayat, Hazha Jamal. Antiproliferative effects and apoptosis induction of ethanolic extract of Andrachna aspera on Human rabdomyosarcoma cells. Iraqi Journal of Cancer and Medical Genetics Vol. 8, no. 1 (2015), pp.46-51.
https://search.emarefa.net/detail/BIM-819037
American Medical Association (AMA)
Hidayat, Hazha Jamal. Antiproliferative effects and apoptosis induction of ethanolic extract of Andrachna aspera on Human rabdomyosarcoma cells. Iraqi Journal of Cancer and Medical Genetics. 2015. Vol. 8, no. 1, pp.46-51.
https://search.emarefa.net/detail/BIM-819037
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-819037