Effects of sub lethal doses of endosulfan on histopathological and biochemical parameters of common carp (Cyprinus carpio)‎

Abstract EN

The study aim to determine the LD50 of endosulfan in fishes.

Sixty (60) fishes of common carp 140-160 gm.

body weight were utilized.

The fishes were adapted and acclimated to the laboratory conditions in the college of Veterinary Medicine, AL-Qassim Green University for 2 days before starting of the experiment, then were exposed to (10 mg/L, 5mg/L, 3mg/L, 2mg/L, 1mg/L) of endosulfan for 24 hours.

Results were demonstrated that the LD50 of endosulfan in fish was (2.28mg/L).

The ALT and AST Liver enzymes were show significant elevation compare with control.

Kidney sections show inflammatory cells infiltration particularly macrophage and neutrophils around the tubules with necrotic area in addition to vacuolar degeneration of epithelial lining cells of renal tubules.

Histological sections of liver show cellular hypertrophy, swelling, and apoptosis of hepatic cells, and at the same time hepatocytes lost their normal polygonal structure in addition to necrosis of hepatocytes.