Role of vitamin E-selenium in ameliorating sub chronic cadmium sulfate toxicity in rabbits

Abstract EN

The study aim to evaluate the ameliorating role of vitamin E-selenium supplementation on serum chemistry and histopathological alterations of liver and heart in rabbits caused by sub chronic cadmium sulfate toxicity.

Twenty white newzealand rabbits of six month old were used and they divided in to two groups' ten animals of each.

G1 given cadmium sulfate 250mg/L in drinking water, G2 were supplemented with cadmium sulfate 250 mg/L plus vitamin E-selenium 500mg/L daily for 60 days.

The results show vitamin E-selenium were significantly improved (P≤0.01) serum ALT, AST, bilirubin, alkaline phosphate, GGT and total protein, while total cholesterol, TG, HDL, LDL, VLDL had some improvement but they didn't reach significant value (P≥0.01), where no changes in the serum myoglobin, troponin and Ck-MP, and the histopathological examinations of liver were confirm these results.

in conclusion supplementation of vitamin E-selenium to the feed of rabbits exposed to sub chronic toxicity of cadmium sulfate reduce the effect of toxicity on the bio indicators of liver in this study.